NET work M eta-analysis of T rials of i nitial O xygen in preterm N ewborns (NETMOTION): A Protocol for Systematic Review and Individual Participant Data Network Meta-Analysis of Preterm Infants <32 Weeks' Gestation Randomized to Initial Oxygen Concentration for Resuscitation

James X. Sotiropoulos, Ju Lee Oei, Georg M. Schmölzer, Kylie E. Hunter, Jonathan G. Williams, Angela C. Webster, Maximo Vento, Vishal Kapadia, Yacov Rabi, Janneke Dekker, Marijn J. Vermeulen, Venkataseshan Sundaram, Praveen Kumar, Ola D. Saugstad, Anna Lene Seidler

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Internationally recognized guidelines recommend the judicious use of low oxygen (21-30%), titrated to peripheral oxygen saturation targets, for the initiation of resuscitation of very and extremely preterm infants (<32 weeks' gestation). However, despite more than 10 randomized controlled trials on this question, the ideal initial oxygen concentration for this group of vulnerable infants remains uncertain. Aims: This study aims to assess the effect of various initial oxygen concentrations on (1) all-cause mortality, chronic lung disease, intraventricular hemorrhage, and retinopathy of prematurity; and (2) reaching the prescribed oxygen saturation targets by 5 min after birth, in preterm infants requiring resuscitation. Methods: We will conduct a systematic review and network meta-analysis using individual participant data. Studies of preterm infants <32 weeks' gestation, randomized to initial oxygen concentration, will be included. We will systematically search medical databases and trial registries for eligible studies (published or unpublished). Records will be screened by two independent reviewers, with conflicts resolved by the inclusion of a third reviewer. Identified initial oxygen concentrations will be grouped into the following nodes: low (≤30%), intermediate (60%), and high (≥90%) oxygen. A two-step random-effects contrast-based network meta-regression will be calculated to compare and rank different oxygen concentrations. Analyses will be intention-to-treat, with the primary outcome of all-cause mortality. Discussion: This is the first individual participant data network meta-analysis of initial oxygen concentrations for the resuscitation of preterm infants. This novel approach may address long-standing uncertainty regarding optimal oxygen supplementation practice for the resuscitation of preterm infants <32 weeks' gestation.

Original languageEnglish (US)
Pages (from-to)517-524
Number of pages8
JournalNeonatology
Volume119
Issue number4
DOIs
StatePublished - Jul 1 2022
Externally publishedYes

Keywords

  • Individual participant data meta-analysis
  • Neonatal resuscitation
  • Network meta-analysis
  • Oxygen concentration
  • Preterm birth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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