Neural and vascular variability and the fMRI-BOLD response in normal aging

Sridhar S. Kannurpatti, Michael A. Motes, Bart Rypma, Bharat B. Biswal

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Neural, vascular and structural variables contributing to the blood oxygen level-dependent (BOLD) signal response variability were investigated in younger and older humans. Twelve younger healthy human subjects (six male and six female; mean age: 24 years; range: 19-27 years) and 12 older healthy subjects (five male and seven female; mean age: 58 years; range: 55-71 years) with no history of head trauma and neurological disease were scanned. Functional magnetic resonance imaging measurements using the BOLD contrast were made when participants performed a motor, cognitive or a breath hold (BH) task. Activation volume and the BOLD response amplitude were estimated for the younger and older at both group and subject levels. Mean activation volume was reduced by 45%, 40% and 38% in the elderly group during the motor, cognitive and BH tasks, respectively, compared to the younger. Reduction in activation volume was substantially higher compared to the reduction in the gray matter volume of 14% in the older compared to the younger. A significantly larger variability in the intersubject BOLD signal change occurred during the motor task, compared to the cognitive task. BH-induced BOLD signal change between subjects was significantly less-variable in the motor task-activated areas in the younger compared to older whereas such a difference between age groups was not observed during the cognitive task. Hemodynamic scaling using the BH signal substantially reduced the BOLD signal variability during the motor task compared to the cognitive task. The results indicate that the origin of the BOLD signal variability between subjects was predominantly vascular during the motor task while being principally a consequence of neural variability during the cognitive task. Thus, in addition to gray matter differences, the type of task performed can have different vascular variability weighting that can influence age-related differences in brain functional response.

Original languageEnglish (US)
Pages (from-to)466-476
Number of pages11
JournalMagnetic Resonance Imaging
Volume28
Issue number4
DOIs
StatePublished - May 2010

Fingerprint

Blood Vessels
Blood
Aging of materials
Magnetic Resonance Imaging
Oxygen
Chemical activation
Healthy Volunteers
Hemodynamics
Blood Volume
Craniocerebral Trauma
Brain
Age Groups

Keywords

  • BOLD
  • Breath hold
  • CBF
  • Cognitive
  • FMRI
  • Hypercapnia
  • Motor
  • Neural
  • Variability
  • Vascular

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Neural and vascular variability and the fMRI-BOLD response in normal aging. / Kannurpatti, Sridhar S.; Motes, Michael A.; Rypma, Bart; Biswal, Bharat B.

In: Magnetic Resonance Imaging, Vol. 28, No. 4, 05.2010, p. 466-476.

Research output: Contribution to journalArticle

Kannurpatti, Sridhar S. ; Motes, Michael A. ; Rypma, Bart ; Biswal, Bharat B. / Neural and vascular variability and the fMRI-BOLD response in normal aging. In: Magnetic Resonance Imaging. 2010 ; Vol. 28, No. 4. pp. 466-476.
@article{94ec4bc42d4d4f2d808923b4336b8637,
title = "Neural and vascular variability and the fMRI-BOLD response in normal aging",
abstract = "Neural, vascular and structural variables contributing to the blood oxygen level-dependent (BOLD) signal response variability were investigated in younger and older humans. Twelve younger healthy human subjects (six male and six female; mean age: 24 years; range: 19-27 years) and 12 older healthy subjects (five male and seven female; mean age: 58 years; range: 55-71 years) with no history of head trauma and neurological disease were scanned. Functional magnetic resonance imaging measurements using the BOLD contrast were made when participants performed a motor, cognitive or a breath hold (BH) task. Activation volume and the BOLD response amplitude were estimated for the younger and older at both group and subject levels. Mean activation volume was reduced by 45{\%}, 40{\%} and 38{\%} in the elderly group during the motor, cognitive and BH tasks, respectively, compared to the younger. Reduction in activation volume was substantially higher compared to the reduction in the gray matter volume of 14{\%} in the older compared to the younger. A significantly larger variability in the intersubject BOLD signal change occurred during the motor task, compared to the cognitive task. BH-induced BOLD signal change between subjects was significantly less-variable in the motor task-activated areas in the younger compared to older whereas such a difference between age groups was not observed during the cognitive task. Hemodynamic scaling using the BH signal substantially reduced the BOLD signal variability during the motor task compared to the cognitive task. The results indicate that the origin of the BOLD signal variability between subjects was predominantly vascular during the motor task while being principally a consequence of neural variability during the cognitive task. Thus, in addition to gray matter differences, the type of task performed can have different vascular variability weighting that can influence age-related differences in brain functional response.",
keywords = "BOLD, Breath hold, CBF, Cognitive, FMRI, Hypercapnia, Motor, Neural, Variability, Vascular",
author = "Kannurpatti, {Sridhar S.} and Motes, {Michael A.} and Bart Rypma and Biswal, {Bharat B.}",
year = "2010",
month = "5",
doi = "10.1016/j.mri.2009.12.007",
language = "English (US)",
volume = "28",
pages = "466--476",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Neural and vascular variability and the fMRI-BOLD response in normal aging

AU - Kannurpatti, Sridhar S.

AU - Motes, Michael A.

AU - Rypma, Bart

AU - Biswal, Bharat B.

PY - 2010/5

Y1 - 2010/5

N2 - Neural, vascular and structural variables contributing to the blood oxygen level-dependent (BOLD) signal response variability were investigated in younger and older humans. Twelve younger healthy human subjects (six male and six female; mean age: 24 years; range: 19-27 years) and 12 older healthy subjects (five male and seven female; mean age: 58 years; range: 55-71 years) with no history of head trauma and neurological disease were scanned. Functional magnetic resonance imaging measurements using the BOLD contrast were made when participants performed a motor, cognitive or a breath hold (BH) task. Activation volume and the BOLD response amplitude were estimated for the younger and older at both group and subject levels. Mean activation volume was reduced by 45%, 40% and 38% in the elderly group during the motor, cognitive and BH tasks, respectively, compared to the younger. Reduction in activation volume was substantially higher compared to the reduction in the gray matter volume of 14% in the older compared to the younger. A significantly larger variability in the intersubject BOLD signal change occurred during the motor task, compared to the cognitive task. BH-induced BOLD signal change between subjects was significantly less-variable in the motor task-activated areas in the younger compared to older whereas such a difference between age groups was not observed during the cognitive task. Hemodynamic scaling using the BH signal substantially reduced the BOLD signal variability during the motor task compared to the cognitive task. The results indicate that the origin of the BOLD signal variability between subjects was predominantly vascular during the motor task while being principally a consequence of neural variability during the cognitive task. Thus, in addition to gray matter differences, the type of task performed can have different vascular variability weighting that can influence age-related differences in brain functional response.

AB - Neural, vascular and structural variables contributing to the blood oxygen level-dependent (BOLD) signal response variability were investigated in younger and older humans. Twelve younger healthy human subjects (six male and six female; mean age: 24 years; range: 19-27 years) and 12 older healthy subjects (five male and seven female; mean age: 58 years; range: 55-71 years) with no history of head trauma and neurological disease were scanned. Functional magnetic resonance imaging measurements using the BOLD contrast were made when participants performed a motor, cognitive or a breath hold (BH) task. Activation volume and the BOLD response amplitude were estimated for the younger and older at both group and subject levels. Mean activation volume was reduced by 45%, 40% and 38% in the elderly group during the motor, cognitive and BH tasks, respectively, compared to the younger. Reduction in activation volume was substantially higher compared to the reduction in the gray matter volume of 14% in the older compared to the younger. A significantly larger variability in the intersubject BOLD signal change occurred during the motor task, compared to the cognitive task. BH-induced BOLD signal change between subjects was significantly less-variable in the motor task-activated areas in the younger compared to older whereas such a difference between age groups was not observed during the cognitive task. Hemodynamic scaling using the BH signal substantially reduced the BOLD signal variability during the motor task compared to the cognitive task. The results indicate that the origin of the BOLD signal variability between subjects was predominantly vascular during the motor task while being principally a consequence of neural variability during the cognitive task. Thus, in addition to gray matter differences, the type of task performed can have different vascular variability weighting that can influence age-related differences in brain functional response.

KW - BOLD

KW - Breath hold

KW - CBF

KW - Cognitive

KW - FMRI

KW - Hypercapnia

KW - Motor

KW - Neural

KW - Variability

KW - Vascular

UR - http://www.scopus.com/inward/record.url?scp=77952288461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952288461&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2009.12.007

DO - 10.1016/j.mri.2009.12.007

M3 - Article

VL - 28

SP - 466

EP - 476

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 4

ER -