Neural blockade during exercise augments central command's contribution to carotid baroreflex resetting

R. G. Querry, S. A. Smith, M. Strømstad, K. Ide, P. B. Raven, N. H. Secher

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

This investigation was designed to determine central command's role on carotid baroreflex (CBR) resetting during exercise. Nine volunteer subjects performed static and rhythmic handgrip exercise at 30 and 40% maximal voluntary contraction (MVC), respectively, before and after partial axillary neural blockade. Stimulus-response curves were developed using the neck pressure-neck suction technique and a rapid pulse train protocol (+40 to -80 Torr). Regional anesthesia resulted in a significant reduction in MVC. Heart rate (HR) and ratings of perceived exertion (RPE) were used as indexes of central command and were elevated during exercise at control force intensity after induced muscle weakness. The CBR function curves were reset vertically with a minimal lateral shift during control exercise and exhibited a further parallel resetting during exercise with neural blockade. The operating point was progressively reset to coincide with the centering point of the CBR curve. These data suggest that central command was a primary mechanism in the resetting of the CBR during exercise. However, it appeared that central command modulated the carotid-cardiac reflex proportionately more than the carotid-vasomotor reflex.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume280
Issue number4 49-4
StatePublished - Apr 2001

Fingerprint

Baroreflex
Exercise
Reflex
Neck
Conduction Anesthesia
Muscle Weakness
Suction
Volunteers
Heart Rate
Pressure

Keywords

  • Anesthesia
  • Blood pressure
  • Cardiovascular control
  • Paralysis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Neural blockade during exercise augments central command's contribution to carotid baroreflex resetting. / Querry, R. G.; Smith, S. A.; Strømstad, M.; Ide, K.; Raven, P. B.; Secher, N. H.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 280, No. 4 49-4, 04.2001.

Research output: Contribution to journalArticle

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