Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder

Alessandra M. Passarotti, John A. Sweeney, Mani N. Pavuluri

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Impulsivity, inattention and poor behavioral inhibition are common deficits in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). This study aimed to identify similarities and differences in the neural substrate of response inhibition deficits that are associated with these disorders. A functional magnetic resonance imaging (fMRI) study was conducted on 15 unmedicated PBD patients (Type I, manic/mixed), 11 unmedicated ADHD patients, and 15 healthy controls (HC) (mean age = 13.5 years; S.D. = 3.5). A response inhibition task examined the ability to inhibit a motor response to a target when a stop cue appeared shortly after. The PBD and ADHD groups did not differ on behavioral performance, although both groups were less accurate than the HC group. fMRI findings showed that for trials requiring response inhibition, the ADHD group, relative to the PBD and HC groups, demonstrated reduced activation in both ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and increased bilateral caudate activation compared with HC. The PBD group, relative to HC, showed decreased activation in the left VLPFC, at the junction of the inferior and middle frontal gyri, and in the right anterior cingulate cortex (ACC). Prefrontal dysfunction was observed in both the ADHD and PBD groups relative to HC, although it was more extensive and accompanied by subcortical overactivity in ADHD.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume181
Issue number1
DOIs
StatePublished - Jan 30 2010

Fingerprint

Attention Deficit Disorder with Hyperactivity
Bipolar Disorder
Pediatrics
Prefrontal Cortex
Magnetic Resonance Imaging
Control Groups
Aptitude
Impulsive Behavior
Gyrus Cinguli
Cues
Inhibition (Psychology)

Keywords

  • Attention
  • Bipolar
  • Child
  • Development
  • Functional magnetic resonance imaging (fMRI)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder. / Passarotti, Alessandra M.; Sweeney, John A.; Pavuluri, Mani N.

In: Psychiatry Research - Neuroimaging, Vol. 181, No. 1, 30.01.2010, p. 36-43.

Research output: Contribution to journalArticle

Passarotti, Alessandra M. ; Sweeney, John A. ; Pavuluri, Mani N. / Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder. In: Psychiatry Research - Neuroimaging. 2010 ; Vol. 181, No. 1. pp. 36-43.
@article{ff1edac9bcc240248bae96d540fc6d5e,
title = "Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder",
abstract = "Impulsivity, inattention and poor behavioral inhibition are common deficits in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). This study aimed to identify similarities and differences in the neural substrate of response inhibition deficits that are associated with these disorders. A functional magnetic resonance imaging (fMRI) study was conducted on 15 unmedicated PBD patients (Type I, manic/mixed), 11 unmedicated ADHD patients, and 15 healthy controls (HC) (mean age = 13.5 years; S.D. = 3.5). A response inhibition task examined the ability to inhibit a motor response to a target when a stop cue appeared shortly after. The PBD and ADHD groups did not differ on behavioral performance, although both groups were less accurate than the HC group. fMRI findings showed that for trials requiring response inhibition, the ADHD group, relative to the PBD and HC groups, demonstrated reduced activation in both ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and increased bilateral caudate activation compared with HC. The PBD group, relative to HC, showed decreased activation in the left VLPFC, at the junction of the inferior and middle frontal gyri, and in the right anterior cingulate cortex (ACC). Prefrontal dysfunction was observed in both the ADHD and PBD groups relative to HC, although it was more extensive and accompanied by subcortical overactivity in ADHD.",
keywords = "Attention, Bipolar, Child, Development, Functional magnetic resonance imaging (fMRI)",
author = "Passarotti, {Alessandra M.} and Sweeney, {John A.} and Pavuluri, {Mani N.}",
year = "2010",
month = "1",
day = "30",
doi = "10.1016/j.pscychresns.2009.07.002",
language = "English (US)",
volume = "181",
pages = "36--43",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Neural correlates of response inhibition in pediatric bipolar disorder and attention deficit hyperactivity disorder

AU - Passarotti, Alessandra M.

AU - Sweeney, John A.

AU - Pavuluri, Mani N.

PY - 2010/1/30

Y1 - 2010/1/30

N2 - Impulsivity, inattention and poor behavioral inhibition are common deficits in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). This study aimed to identify similarities and differences in the neural substrate of response inhibition deficits that are associated with these disorders. A functional magnetic resonance imaging (fMRI) study was conducted on 15 unmedicated PBD patients (Type I, manic/mixed), 11 unmedicated ADHD patients, and 15 healthy controls (HC) (mean age = 13.5 years; S.D. = 3.5). A response inhibition task examined the ability to inhibit a motor response to a target when a stop cue appeared shortly after. The PBD and ADHD groups did not differ on behavioral performance, although both groups were less accurate than the HC group. fMRI findings showed that for trials requiring response inhibition, the ADHD group, relative to the PBD and HC groups, demonstrated reduced activation in both ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and increased bilateral caudate activation compared with HC. The PBD group, relative to HC, showed decreased activation in the left VLPFC, at the junction of the inferior and middle frontal gyri, and in the right anterior cingulate cortex (ACC). Prefrontal dysfunction was observed in both the ADHD and PBD groups relative to HC, although it was more extensive and accompanied by subcortical overactivity in ADHD.

AB - Impulsivity, inattention and poor behavioral inhibition are common deficits in pediatric bipolar disorder (PBD) and attention deficit hyperactivity disorder (ADHD). This study aimed to identify similarities and differences in the neural substrate of response inhibition deficits that are associated with these disorders. A functional magnetic resonance imaging (fMRI) study was conducted on 15 unmedicated PBD patients (Type I, manic/mixed), 11 unmedicated ADHD patients, and 15 healthy controls (HC) (mean age = 13.5 years; S.D. = 3.5). A response inhibition task examined the ability to inhibit a motor response to a target when a stop cue appeared shortly after. The PBD and ADHD groups did not differ on behavioral performance, although both groups were less accurate than the HC group. fMRI findings showed that for trials requiring response inhibition, the ADHD group, relative to the PBD and HC groups, demonstrated reduced activation in both ventrolateral (VLPFC) and dorsolateral (DLPFC) prefrontal cortex, and increased bilateral caudate activation compared with HC. The PBD group, relative to HC, showed decreased activation in the left VLPFC, at the junction of the inferior and middle frontal gyri, and in the right anterior cingulate cortex (ACC). Prefrontal dysfunction was observed in both the ADHD and PBD groups relative to HC, although it was more extensive and accompanied by subcortical overactivity in ADHD.

KW - Attention

KW - Bipolar

KW - Child

KW - Development

KW - Functional magnetic resonance imaging (fMRI)

UR - http://www.scopus.com/inward/record.url?scp=71849100430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71849100430&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2009.07.002

DO - 10.1016/j.pscychresns.2009.07.002

M3 - Article

C2 - 19926457

AN - SCOPUS:71849100430

VL - 181

SP - 36

EP - 43

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 1

ER -