TY - JOUR
T1 - Neural damage in the Guinea pig cochlea after noise exposure a light microscopic study
AU - Wright, G.
N1 - Funding Information:
Support for this work was provided by the Deafness Research Foundation, NINDS, USPHS Research Grant NS 05065 and Program Project Grant NS 05785.
PY - 1976
Y1 - 1976
N2 - Neural damage produced by exposure to 8 kHz octave-band noise was studied by light microscopy in guinea pigs. Abnormal nerve endings were found beneath both inner and outer hair cells within 24 hours after exposure at either 118 or 120 dB SPL. In areas where the organ of Corti was destroyed degeneration of myelinated nerve fibers was seen immediately after 24-hour exposures. Nerve degeneration secondary to hair cell loss was observed. However, degeneration of myelinated fibers occurred in some cases without significant hair cell loss. At survival times as long as two months nerve fibers coursing near capillaries were still present in extensively damaged areas. In three animals nerve fibers which had apparently regenerated into regions where the sensory epithelium was destroyed were found distal to the habenula perforata. Evidence of regenerative activity was also noted in the osseous spiral lamina.
AB - Neural damage produced by exposure to 8 kHz octave-band noise was studied by light microscopy in guinea pigs. Abnormal nerve endings were found beneath both inner and outer hair cells within 24 hours after exposure at either 118 or 120 dB SPL. In areas where the organ of Corti was destroyed degeneration of myelinated nerve fibers was seen immediately after 24-hour exposures. Nerve degeneration secondary to hair cell loss was observed. However, degeneration of myelinated fibers occurred in some cases without significant hair cell loss. At survival times as long as two months nerve fibers coursing near capillaries were still present in extensively damaged areas. In three animals nerve fibers which had apparently regenerated into regions where the sensory epithelium was destroyed were found distal to the habenula perforata. Evidence of regenerative activity was also noted in the osseous spiral lamina.
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U2 - 10.3109/00016487609120865
DO - 10.3109/00016487609120865
M3 - Article
C2 - 948988
AN - SCOPUS:0017130080
SN - 0001-6489
VL - 82
SP - 82
EP - 94
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 1-6
ER -