Neural hyperexcitability in autism spectrum disorders

Yukari Takarae; John Sweeney

doi:10.3390/brainsci7100129

Neural hyperexcitability in autism spectrum disorders

Yukari Takarae, John Sweeney

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD. Applications of the cortical excitability model for translational research and drug development are also discussed.

Original language	English (US)
Article number	129
Journal	Brain Sciences
Volume	7
Issue number	10
DOIs	https://doi.org/10.3390/brainsci7100129
State	Published - Oct 13 2017

Keywords

Autism
Individual differences
Inhibition
Sensory abnormalities
Sensory hypersensitivity
Sensory hyposensitivity

ASJC Scopus subject areas

General Neuroscience

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10.3390/brainsci7100129

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abstract = "Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD. Applications of the cortical excitability model for translational research and drug development are also discussed.",

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AB - Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD. Applications of the cortical excitability model for translational research and drug development are also discussed.

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KW - Inhibition

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KW - Sensory hypersensitivity

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Neural hyperexcitability in autism spectrum disorders

Abstract

Keywords

ASJC Scopus subject areas

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