Neural response to lidocaine in healthy subjects

Bryon Adinoff, Michael D. Devous, Donald C. Cooper, Susan E. Best, Thomas S. Harris, Mark J. Williams

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent studies suggest that some of cocaine's central nervous system (CNS) effects may be mediated through its sodium channel inhibiting local anesthetic properties. Local anesthetics that lack cocaine's strong affinity for the dopamine transporter (DAT) also produce sensory and mood effects, further suggesting a role for this neural pathway. Due to an absence of affinity at the DAT, the local anesthetic lidocaine may offer the potential to assess sodium channel activity in vivo in humans. To assess the utility of lidocaine as a CNS probe, we determined regional cerebral blood flow (rCBF) with single photon emission computed tomography (SPECT) following the intravenous administration of lidocaine (0.5 mg/kg) and compared this response to procaine (0.5 mg/kg and 1.0 mg/kg), a local anesthetic with partial affinity for the DAT, and saline. Infusions were administered in nine healthy female controls over a 10-day period with at least 2 days between each scan. Increased rCBF was observed following lidocaine, relative to saline, in the insula, caudate, thalamus, and posterior cingulate. Decreased rCBF was detected in a different region of the posterior cingulate. In general, increases in rCBF were more marked following lidocaine relative to procaine. Mood and sensory changes following lidocaine were limited and significantly less than those induced by either dose of procaine. There were no significant changes in blood pressure or heart rate following either medication. These findings suggest that lidocaine can be safely used to assess sodium channel function in persons with addictive and other psychiatric disorders.

Original languageEnglish (US)
Pages (from-to)135-142
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume173
Issue number2
DOIs
StatePublished - Aug 30 2009

Fingerprint

Lidocaine
Cerebrovascular Circulation
Healthy Volunteers
Regional Blood Flow
Local Anesthetics
Dopamine Plasma Membrane Transport Proteins
Procaine
Sodium Channels
Gyrus Cinguli
Cocaine
Central Nervous System
Neural Pathways
Single-Photon Emission-Computed Tomography
Thalamus
Intravenous Administration
Psychiatry
Heart Rate
Blood Pressure

Keywords

  • Anesthetics
  • Basal ganglia
  • Emission computed
  • Humans
  • Lidocaine
  • Limbic system
  • Local
  • Procaine
  • Single photon
  • Tomography

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

Adinoff, B., Devous, M. D., Cooper, D. C., Best, S. E., Harris, T. S., & Williams, M. J. (2009). Neural response to lidocaine in healthy subjects. Psychiatry Research - Neuroimaging, 173(2), 135-142. https://doi.org/10.1016/j.pscychresns.2009.03.001

Neural response to lidocaine in healthy subjects. / Adinoff, Bryon; Devous, Michael D.; Cooper, Donald C.; Best, Susan E.; Harris, Thomas S.; Williams, Mark J.

In: Psychiatry Research - Neuroimaging, Vol. 173, No. 2, 30.08.2009, p. 135-142.

Research output: Contribution to journalArticle

Adinoff, B, Devous, MD, Cooper, DC, Best, SE, Harris, TS & Williams, MJ 2009, 'Neural response to lidocaine in healthy subjects', Psychiatry Research - Neuroimaging, vol. 173, no. 2, pp. 135-142. https://doi.org/10.1016/j.pscychresns.2009.03.001
Adinoff, Bryon ; Devous, Michael D. ; Cooper, Donald C. ; Best, Susan E. ; Harris, Thomas S. ; Williams, Mark J. / Neural response to lidocaine in healthy subjects. In: Psychiatry Research - Neuroimaging. 2009 ; Vol. 173, No. 2. pp. 135-142.
@article{02693c3ce8ab412b977601ee956e74fe,
title = "Neural response to lidocaine in healthy subjects",
abstract = "Recent studies suggest that some of cocaine's central nervous system (CNS) effects may be mediated through its sodium channel inhibiting local anesthetic properties. Local anesthetics that lack cocaine's strong affinity for the dopamine transporter (DAT) also produce sensory and mood effects, further suggesting a role for this neural pathway. Due to an absence of affinity at the DAT, the local anesthetic lidocaine may offer the potential to assess sodium channel activity in vivo in humans. To assess the utility of lidocaine as a CNS probe, we determined regional cerebral blood flow (rCBF) with single photon emission computed tomography (SPECT) following the intravenous administration of lidocaine (0.5 mg/kg) and compared this response to procaine (0.5 mg/kg and 1.0 mg/kg), a local anesthetic with partial affinity for the DAT, and saline. Infusions were administered in nine healthy female controls over a 10-day period with at least 2 days between each scan. Increased rCBF was observed following lidocaine, relative to saline, in the insula, caudate, thalamus, and posterior cingulate. Decreased rCBF was detected in a different region of the posterior cingulate. In general, increases in rCBF were more marked following lidocaine relative to procaine. Mood and sensory changes following lidocaine were limited and significantly less than those induced by either dose of procaine. There were no significant changes in blood pressure or heart rate following either medication. These findings suggest that lidocaine can be safely used to assess sodium channel function in persons with addictive and other psychiatric disorders.",
keywords = "Anesthetics, Basal ganglia, Emission computed, Humans, Lidocaine, Limbic system, Local, Procaine, Single photon, Tomography",
author = "Bryon Adinoff and Devous, {Michael D.} and Cooper, {Donald C.} and Best, {Susan E.} and Harris, {Thomas S.} and Williams, {Mark J.}",
year = "2009",
month = "8",
day = "30",
doi = "10.1016/j.pscychresns.2009.03.001",
language = "English (US)",
volume = "173",
pages = "135--142",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Neural response to lidocaine in healthy subjects

AU - Adinoff, Bryon

AU - Devous, Michael D.

AU - Cooper, Donald C.

AU - Best, Susan E.

AU - Harris, Thomas S.

AU - Williams, Mark J.

PY - 2009/8/30

Y1 - 2009/8/30

N2 - Recent studies suggest that some of cocaine's central nervous system (CNS) effects may be mediated through its sodium channel inhibiting local anesthetic properties. Local anesthetics that lack cocaine's strong affinity for the dopamine transporter (DAT) also produce sensory and mood effects, further suggesting a role for this neural pathway. Due to an absence of affinity at the DAT, the local anesthetic lidocaine may offer the potential to assess sodium channel activity in vivo in humans. To assess the utility of lidocaine as a CNS probe, we determined regional cerebral blood flow (rCBF) with single photon emission computed tomography (SPECT) following the intravenous administration of lidocaine (0.5 mg/kg) and compared this response to procaine (0.5 mg/kg and 1.0 mg/kg), a local anesthetic with partial affinity for the DAT, and saline. Infusions were administered in nine healthy female controls over a 10-day period with at least 2 days between each scan. Increased rCBF was observed following lidocaine, relative to saline, in the insula, caudate, thalamus, and posterior cingulate. Decreased rCBF was detected in a different region of the posterior cingulate. In general, increases in rCBF were more marked following lidocaine relative to procaine. Mood and sensory changes following lidocaine were limited and significantly less than those induced by either dose of procaine. There were no significant changes in blood pressure or heart rate following either medication. These findings suggest that lidocaine can be safely used to assess sodium channel function in persons with addictive and other psychiatric disorders.

AB - Recent studies suggest that some of cocaine's central nervous system (CNS) effects may be mediated through its sodium channel inhibiting local anesthetic properties. Local anesthetics that lack cocaine's strong affinity for the dopamine transporter (DAT) also produce sensory and mood effects, further suggesting a role for this neural pathway. Due to an absence of affinity at the DAT, the local anesthetic lidocaine may offer the potential to assess sodium channel activity in vivo in humans. To assess the utility of lidocaine as a CNS probe, we determined regional cerebral blood flow (rCBF) with single photon emission computed tomography (SPECT) following the intravenous administration of lidocaine (0.5 mg/kg) and compared this response to procaine (0.5 mg/kg and 1.0 mg/kg), a local anesthetic with partial affinity for the DAT, and saline. Infusions were administered in nine healthy female controls over a 10-day period with at least 2 days between each scan. Increased rCBF was observed following lidocaine, relative to saline, in the insula, caudate, thalamus, and posterior cingulate. Decreased rCBF was detected in a different region of the posterior cingulate. In general, increases in rCBF were more marked following lidocaine relative to procaine. Mood and sensory changes following lidocaine were limited and significantly less than those induced by either dose of procaine. There were no significant changes in blood pressure or heart rate following either medication. These findings suggest that lidocaine can be safely used to assess sodium channel function in persons with addictive and other psychiatric disorders.

KW - Anesthetics

KW - Basal ganglia

KW - Emission computed

KW - Humans

KW - Lidocaine

KW - Limbic system

KW - Local

KW - Procaine

KW - Single photon

KW - Tomography

UR - http://www.scopus.com/inward/record.url?scp=67651112208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67651112208&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2009.03.001

DO - 10.1016/j.pscychresns.2009.03.001

M3 - Article

VL - 173

SP - 135

EP - 142

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 2

ER -