Neural response to the second stimulus associated with poor speed discrimination performance in schizophrenia

Jun Wang, Karen R. Dobkins, Jennifer E. Mcdowell, Brett A. Clementz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Visual motion processing is compromised in schizophrenia (SZ), but it is uncertain what neural deviations account for their motion analysis abnormalities. Neural activations were measured with dense-array electroencephalography while 14 medicated SZ and 14 healthy persons performed a paired-stimuli forced choice speed discrimination task. SZ had (a) worse-at-speed discrimination, replicating previous findings, (b) normal early extrastriate neural activity (N1) to both motion stimuli, (c) reduced later extrastriate activity (P2) specifically to the second stimulus, and (d) following P2, an enhanced later N2 over parietal cortex. Stronger P2 and N2 responses were associated with better speed discrimination performance across groups. These findings indicate that the neural correlates of poor motion analysis in SZ may not be an early visual analysis abnormality but a problem with efficient use of speed information later in cognitive processing.

Original languageEnglish (US)
Pages (from-to)198-206
Number of pages9
JournalPsychophysiology
Volume49
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Schizophrenia
Parietal Lobe
Electroencephalography
Stimulus
Discrimination

Keywords

  • Evoked potentials
  • Motion
  • Parietal cortex
  • Smooth pursuit
  • Visual

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Neural response to the second stimulus associated with poor speed discrimination performance in schizophrenia. / Wang, Jun; Dobkins, Karen R.; Mcdowell, Jennifer E.; Clementz, Brett A.

In: Psychophysiology, Vol. 49, No. 2, 02.2012, p. 198-206.

Research output: Contribution to journalArticle

Wang, Jun ; Dobkins, Karen R. ; Mcdowell, Jennifer E. ; Clementz, Brett A. / Neural response to the second stimulus associated with poor speed discrimination performance in schizophrenia. In: Psychophysiology. 2012 ; Vol. 49, No. 2. pp. 198-206.
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