Neural substrates of orthographic lexical access as demonstrated by functional brain imaging

John Hart, Michael A. Kraut, Sarah Kremen, Brian Sober, Barry Gordon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To delineate regions involved in visual word recognition. Background: The processes and regions involved in visual word recognition have been somewhat controversial for over 100 years. Methods: This study used regional cerebral blood flow as assessed by functional magnetic resonance imaging to study normal subjects (N = 9) on an individual within-subject basis while they were actively engaged on-line in a visual lexical decision task. Standard analysis techniques were used for identifying regions of activation. Results: Across subjects, the task activated a number of regions, including the occipital pole, lateral and basal occipitotemporal (including lingual and fusiform) regions, superior and middle temporal gyri, and supramarginal and angular gyri. Typically, these regions were activated bilaterally; when activation was unilateral, it was on the left. Some of the areas activated (e.g., inferior parietal regions) have not been previously reported to be involved in such types of processing by activation studies but have been implicated in lesion studies. Conclusions: These results broaden the areas known to be involved in visual word recognition. The bilateral activation associated with visual word recognition is in some respects analogous to the 'what' system in visual recognition described in subhuman primates. In addition, the study raises several methodologic issues. The within-subject analysis showed variability in the specific regions activated when subsequently comparing across individuals, raising implications for future functional imaging studies.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalNeuropsychiatry, Neuropsychology and Behavioral Neurology
Volume13
Issue number1
StatePublished - Jan 2000

Fingerprint

Parietal Lobe
Functional Neuroimaging
Cerebrovascular Circulation
Occipital Lobe
Regional Blood Flow
Temporal Lobe
Tongue
Primates
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Neural substrates of orthographic lexical access as demonstrated by functional brain imaging. / Hart, John; Kraut, Michael A.; Kremen, Sarah; Sober, Brian; Gordon, Barry.

In: Neuropsychiatry, Neuropsychology and Behavioral Neurology, Vol. 13, No. 1, 01.2000, p. 1-7.

Research output: Contribution to journalArticle

Hart, John ; Kraut, Michael A. ; Kremen, Sarah ; Sober, Brian ; Gordon, Barry. / Neural substrates of orthographic lexical access as demonstrated by functional brain imaging. In: Neuropsychiatry, Neuropsychology and Behavioral Neurology. 2000 ; Vol. 13, No. 1. pp. 1-7.
@article{e28514ef4cb94f93a65567a68eee9e8e,
title = "Neural substrates of orthographic lexical access as demonstrated by functional brain imaging",
abstract = "Objective: To delineate regions involved in visual word recognition. Background: The processes and regions involved in visual word recognition have been somewhat controversial for over 100 years. Methods: This study used regional cerebral blood flow as assessed by functional magnetic resonance imaging to study normal subjects (N = 9) on an individual within-subject basis while they were actively engaged on-line in a visual lexical decision task. Standard analysis techniques were used for identifying regions of activation. Results: Across subjects, the task activated a number of regions, including the occipital pole, lateral and basal occipitotemporal (including lingual and fusiform) regions, superior and middle temporal gyri, and supramarginal and angular gyri. Typically, these regions were activated bilaterally; when activation was unilateral, it was on the left. Some of the areas activated (e.g., inferior parietal regions) have not been previously reported to be involved in such types of processing by activation studies but have been implicated in lesion studies. Conclusions: These results broaden the areas known to be involved in visual word recognition. The bilateral activation associated with visual word recognition is in some respects analogous to the 'what' system in visual recognition described in subhuman primates. In addition, the study raises several methodologic issues. The within-subject analysis showed variability in the specific regions activated when subsequently comparing across individuals, raising implications for future functional imaging studies.",
author = "John Hart and Kraut, {Michael A.} and Sarah Kremen and Brian Sober and Barry Gordon",
year = "2000",
month = "1",
language = "English (US)",
volume = "13",
pages = "1--7",
journal = "Cognitive and Behavioral Neurology",
issn = "1543-3633",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Neural substrates of orthographic lexical access as demonstrated by functional brain imaging

AU - Hart, John

AU - Kraut, Michael A.

AU - Kremen, Sarah

AU - Sober, Brian

AU - Gordon, Barry

PY - 2000/1

Y1 - 2000/1

N2 - Objective: To delineate regions involved in visual word recognition. Background: The processes and regions involved in visual word recognition have been somewhat controversial for over 100 years. Methods: This study used regional cerebral blood flow as assessed by functional magnetic resonance imaging to study normal subjects (N = 9) on an individual within-subject basis while they were actively engaged on-line in a visual lexical decision task. Standard analysis techniques were used for identifying regions of activation. Results: Across subjects, the task activated a number of regions, including the occipital pole, lateral and basal occipitotemporal (including lingual and fusiform) regions, superior and middle temporal gyri, and supramarginal and angular gyri. Typically, these regions were activated bilaterally; when activation was unilateral, it was on the left. Some of the areas activated (e.g., inferior parietal regions) have not been previously reported to be involved in such types of processing by activation studies but have been implicated in lesion studies. Conclusions: These results broaden the areas known to be involved in visual word recognition. The bilateral activation associated with visual word recognition is in some respects analogous to the 'what' system in visual recognition described in subhuman primates. In addition, the study raises several methodologic issues. The within-subject analysis showed variability in the specific regions activated when subsequently comparing across individuals, raising implications for future functional imaging studies.

AB - Objective: To delineate regions involved in visual word recognition. Background: The processes and regions involved in visual word recognition have been somewhat controversial for over 100 years. Methods: This study used regional cerebral blood flow as assessed by functional magnetic resonance imaging to study normal subjects (N = 9) on an individual within-subject basis while they were actively engaged on-line in a visual lexical decision task. Standard analysis techniques were used for identifying regions of activation. Results: Across subjects, the task activated a number of regions, including the occipital pole, lateral and basal occipitotemporal (including lingual and fusiform) regions, superior and middle temporal gyri, and supramarginal and angular gyri. Typically, these regions were activated bilaterally; when activation was unilateral, it was on the left. Some of the areas activated (e.g., inferior parietal regions) have not been previously reported to be involved in such types of processing by activation studies but have been implicated in lesion studies. Conclusions: These results broaden the areas known to be involved in visual word recognition. The bilateral activation associated with visual word recognition is in some respects analogous to the 'what' system in visual recognition described in subhuman primates. In addition, the study raises several methodologic issues. The within-subject analysis showed variability in the specific regions activated when subsequently comparing across individuals, raising implications for future functional imaging studies.

UR - http://www.scopus.com/inward/record.url?scp=0033977828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033977828&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 1

EP - 7

JO - Cognitive and Behavioral Neurology

JF - Cognitive and Behavioral Neurology

SN - 1543-3633

IS - 1

ER -