Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans

Zhitao Hu, Sabrina Hom, Tambudzai Kudze, Xia Jing Tong, Seungwon Choi, Gayane Aramuni, Weiqi Zhang, Joshua M. Kaplan

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The synaptic adhesion molecules neurexin and neuroligin alter the development and function of synapses and are linked to autism in humans. Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. Retrograde signaling was induced in mutants lacking a muscle microRNA (miR-1) and was blocked in mutants lacking NLG-1 or NRX-1. Release was rapid and abbreviated when the retrograde signal was on, whereas release was slow and prolonged when retrograde signaling was blocked. The retrograde signal adjusted release kinetics by inhibiting exocytosis of synaptic vesicles (SVs) that are distal to the site of calcium entry. Inhibition of release was mediated by increased presynaptic levels of tomosyn, an inhibitor of SV fusion.

Original languageEnglish (US)
Pages (from-to)980-984
Number of pages5
JournalScience
Volume337
Issue number6097
DOIs
StatePublished - Aug 24 2012
Externally publishedYes

ASJC Scopus subject areas

  • General

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