Neuroactive peptides exist in the midbrain dopaminergic neurons that contain calbindin-D28k

D. C. German, C. L. Liang

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

CALBiNDiN-D28k, a calcium-binding protein, has been identified within a subpopulation of midbrain dopaminergic (DA) neurons in rats, monkeys and humans. The neuroactive peptides CCK and neurotensin also have been found in a subpopulation of midbrain DA neurons. Using double- and triple-labeling immunocytochemical staining procedures in the rat, we now report that the midbrain DA neurons that contain the peptides also contain calbin-din-D28k. Calbindin-D28k may play a role in the co-release of neuroactive peptides with dopamine from the midbrain DA neurons.

Original languageEnglish (US)
Pages (from-to)491-494
Number of pages4
JournalNeuroReport
Volume4
Issue number5
DOIs
StatePublished - May 1993

Keywords

  • Calbindin-D
  • Cholecystokinin (CCK)
  • Double-and Triple-labeling immunocytochemistry
  • Midbrain dopaminergic (DA) neurons
  • Neurotensin

ASJC Scopus subject areas

  • Neuroscience(all)

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