Neuroactive peptides exist in the midbrain dopaminergic neurons that contain calbindin-D(28k)

D. C. German, C. L. Liang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Calbindin-D(28k), a calcium-binding protein, has been identified within a subpopulation of midbrain dopaminergic (DA) neurons in rats, monkeys and humans. The neuroactive peptides CCK and neurotensin also have been found in a subpopulation of midbrain DA neurons. Using double- and triple-labeling immunocytochemical staining procedures in the rat, we now report that the midbrain DA neurons that contain the peptides also contain calbindin-D(28k). Calbindin-D(28k) may play a role in the co-release of neuroactive peptides with dopamine from the midbrain DA neurons.

Original languageEnglish (US)
Pages (from-to)491-494
Number of pages4
JournalNeuroReport
Volume4
Issue number5
StatePublished - 1993

Fingerprint

Calbindins
Dopaminergic Neurons
Mesencephalon
Peptides
Neurotensin
Calcium-Binding Proteins
Haplorhini
Dopamine
Staining and Labeling

Keywords

  • calbindin-D(28k)
  • cholecystokinin (CCK)
  • double- and triple-labeling immunocytochemistry
  • midbrain dopaminergic (DA) neurons
  • neurotensin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroactive peptides exist in the midbrain dopaminergic neurons that contain calbindin-D(28k). / German, D. C.; Liang, C. L.

In: NeuroReport, Vol. 4, No. 5, 1993, p. 491-494.

Research output: Contribution to journalArticle

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