Neuroanatomic organization of the parasympathetic bronchomotor system in developing sheep

J. Julio Pérez Fontán, Christine R. Velloff

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We applied two complementary retrograde labeling techniques to characterize the organization of the brain stem neuronal network responsible for the vagal innervation of the trachealis muscle in developing sheep. Single neuronal labeling produced by injections of the β-subunit of cholera toxin into the muscle in newborn lambs showed that airway vagal preganglionic neurons are located exclusively in the nucleus ambiguus and nucleus of the solitary tract. Transneuronal labeling produced by similar injections of the Bartha strain of the pseudorabies virus in sheep fetuses demonstrated that these airway vagal preganglionic neurons receive inputs from a small number of neurons in brain stem areas known to participate in premotor control of the respiratory muscles (ventral respiratory group), chemoreception (nucleus of the solitary tract and ventral medullary surface), and cardiovascular and respiratory regulation (raphe nuclei, ventrolateral medulla, and noradrenergic groups of the medulla and pons). We conclude that the vagal preganglionic neurons that project to airway smooth muscle are already integrated in the control of breathing before birth in sheep.

Original languageEnglish (US)
Pages (from-to)R121-R133
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume273
Issue number1 42-1
DOIs
StatePublished - Jul 1997

Keywords

  • Airway smooth muscle
  • Cholera toxin
  • Control of breathing
  • Lung innervation
  • Pseudorabies virus

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'Neuroanatomic organization of the parasympathetic bronchomotor system in developing sheep'. Together they form a unique fingerprint.

Cite this