Neuroanatomical substrates of depression in the elderly

K. Ranga R Krishnan; William M. McDonald; P. Murali Doraiswamy; Larry A. Tupler; Mustafa Husain; Orest B. Boyko; Gary S. Figiel; Everett H. Ellinwood

doi:10.1007/BF02191522

Neuroanatomical substrates of depression in the elderly

K. Ranga R Krishnan, William M. McDonald, P. Murali Doraiswamy, Larry A. Tupler, Mustafa Husain, Orest B. Boyko, Gary S. Figiel, Everett H. Ellinwood

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

The etiology of depression in the elderly is poorly understood. In this study, magnetic resonance imaging was used to evaluate the role of subcortical structures in the pathophysiology of depression in the elderly. Elderly depressed patients were found to have smaller caudate nuclei, smaller putaminal complexes and in increased frequency of subcortical hyperintensities compared with normal, healthy controls. These findings were more pronounced in patients with lateonset depression. Based on these findings, the authors discuss the role of the basal ganglia in the pathophysiology of depression in the elderly.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	243
Issue number	1
DOIs	https://doi.org/10.1007/BF02191522
State	Published - Jul 1993

Keywords

Basal ganglia
Depression
Magnetic resonance imaging
Subcortical hyperintensities

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

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10.1007/BF02191522

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title = "Neuroanatomical substrates of depression in the elderly",

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AU - Husain, Mustafa

AU - Boyko, Orest B.

AU - Figiel, Gary S.

AU - Ellinwood, Everett H.

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KW - Depression

KW - Magnetic resonance imaging

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Neuroanatomical substrates of depression in the elderly

Abstract

Keywords

ASJC Scopus subject areas

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