Neurobiology of glaucomatous optic neuropathy

Diverse cellular events in neurodegeneration and neuroprotection

M. B. Wax, G. Tezel

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Although glaucomatous optic nerve degeneration is a leading cause of worldwide blindness, neither the precise cellular mechanisms underlying neurodegeneration in glaucoma, nor effective strategies for neuroprotection are yet clear. This review focuses on diverse cellular events associated with glaucomatous neurodegeneration whose balance is critical for determination of ultimate cell fate. An improved understanding of the site of primary injury to optic nerve, the mediator pathways of apoptotic cell death and intrinsic protection mechanisms in retinal ganglion cells, the role of glial activation on the survival and death of retinal ganglion cell bodies and their axons, and the protective and destructive consequences of immune system involvement can facilitate development of effective neuroprotective strategies in glaucoma.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalMolecular Neurobiology
Volume26
Issue number1
StatePublished - Aug 2002

Fingerprint

Optic Nerve Diseases
Neurobiology
Retinal Ganglion Cells
Glaucoma
Optic Nerve Injuries
Nerve Degeneration
Blindness
Optic Nerve
Neuroglia
Axons
Immune System
Cell Death
Neuroprotection
Cell Body

Keywords

  • Apoptosis
  • Glaucoma
  • Neurodegeneration
  • Neuroprotection
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Neurobiology of glaucomatous optic neuropathy : Diverse cellular events in neurodegeneration and neuroprotection. / Wax, M. B.; Tezel, G.

In: Molecular Neurobiology, Vol. 26, No. 1, 08.2002, p. 45-55.

Research output: Contribution to journalArticle

@article{f90fb39cbdc0478e9473e09f56ef9b9c,
title = "Neurobiology of glaucomatous optic neuropathy: Diverse cellular events in neurodegeneration and neuroprotection",
abstract = "Although glaucomatous optic nerve degeneration is a leading cause of worldwide blindness, neither the precise cellular mechanisms underlying neurodegeneration in glaucoma, nor effective strategies for neuroprotection are yet clear. This review focuses on diverse cellular events associated with glaucomatous neurodegeneration whose balance is critical for determination of ultimate cell fate. An improved understanding of the site of primary injury to optic nerve, the mediator pathways of apoptotic cell death and intrinsic protection mechanisms in retinal ganglion cells, the role of glial activation on the survival and death of retinal ganglion cell bodies and their axons, and the protective and destructive consequences of immune system involvement can facilitate development of effective neuroprotective strategies in glaucoma.",
keywords = "Apoptosis, Glaucoma, Neurodegeneration, Neuroprotection, Retinal ganglion cells",
author = "Wax, {M. B.} and G. Tezel",
year = "2002",
month = "8",
language = "English (US)",
volume = "26",
pages = "45--55",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Humana Press",
number = "1",

}

TY - JOUR

T1 - Neurobiology of glaucomatous optic neuropathy

T2 - Diverse cellular events in neurodegeneration and neuroprotection

AU - Wax, M. B.

AU - Tezel, G.

PY - 2002/8

Y1 - 2002/8

N2 - Although glaucomatous optic nerve degeneration is a leading cause of worldwide blindness, neither the precise cellular mechanisms underlying neurodegeneration in glaucoma, nor effective strategies for neuroprotection are yet clear. This review focuses on diverse cellular events associated with glaucomatous neurodegeneration whose balance is critical for determination of ultimate cell fate. An improved understanding of the site of primary injury to optic nerve, the mediator pathways of apoptotic cell death and intrinsic protection mechanisms in retinal ganglion cells, the role of glial activation on the survival and death of retinal ganglion cell bodies and their axons, and the protective and destructive consequences of immune system involvement can facilitate development of effective neuroprotective strategies in glaucoma.

AB - Although glaucomatous optic nerve degeneration is a leading cause of worldwide blindness, neither the precise cellular mechanisms underlying neurodegeneration in glaucoma, nor effective strategies for neuroprotection are yet clear. This review focuses on diverse cellular events associated with glaucomatous neurodegeneration whose balance is critical for determination of ultimate cell fate. An improved understanding of the site of primary injury to optic nerve, the mediator pathways of apoptotic cell death and intrinsic protection mechanisms in retinal ganglion cells, the role of glial activation on the survival and death of retinal ganglion cell bodies and their axons, and the protective and destructive consequences of immune system involvement can facilitate development of effective neuroprotective strategies in glaucoma.

KW - Apoptosis

KW - Glaucoma

KW - Neurodegeneration

KW - Neuroprotection

KW - Retinal ganglion cells

UR - http://www.scopus.com/inward/record.url?scp=0036700129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036700129&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 45

EP - 55

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 1

ER -