Neurobiology of glaucomatous optic neuropathy: Diverse cellular events in neurodegeneration and neuroprotection

M. B. Wax, G. Tezel

Research output: Contribution to journalReview article

92 Scopus citations

Abstract

Although glaucomatous optic nerve degeneration is a leading cause of worldwide blindness, neither the precise cellular mechanisms underlying neurodegeneration in glaucoma, nor effective strategies for neuroprotection are yet clear. This review focuses on diverse cellular events associated with glaucomatous neurodegeneration whose balance is critical for determination of ultimate cell fate. An improved understanding of the site of primary injury to optic nerve, the mediator pathways of apoptotic cell death and intrinsic protection mechanisms in retinal ganglion cells, the role of glial activation on the survival and death of retinal ganglion cell bodies and their axons, and the protective and destructive consequences of immune system involvement can facilitate development of effective neuroprotective strategies in glaucoma.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalMolecular Neurobiology
Volume26
Issue number1
DOIs
StatePublished - Aug 2002

Keywords

  • Apoptosis
  • Glaucoma
  • Neurodegeneration
  • Neuroprotection
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Neurobiology of glaucomatous optic neuropathy: Diverse cellular events in neurodegeneration and neuroprotection'. Together they form a unique fingerprint.

  • Cite this