Neurobiologie de l'anorexie inflammatoire

Translated title of the contribution: Neurobiology of inflammation-associated anorexia

L. Gautron, S. Layé

Research output: Contribution to journalArticle

Abstract

Cytokines play a key role in mediating inflammation-associated anorexia. Compelling data demonstrate that cytokines can stimulate the activity of the peripheral nervous system and induce de novo synthesis of pro-inflammatory factors in the brain. It results in the stimulation of a specific neural circuit that reduces food intake. The melanocortinergic pathway tightly regulates the activity of this neural circuit upon humoral and environmental changes. Identifying the mechanisms underlying inflammation-associated anorexia is a true challenge geared toward the fight against loss of appetite in cancer patients.

Original languageFrench
Pages (from-to)105-113
Number of pages9
JournalObesite
Volume6
Issue number2
DOIs
StatePublished - 2011

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Keywords

  • Appetite
  • Brain
  • Cachexia
  • Inflammation
  • Interleukin-1

ASJC Scopus subject areas

  • Medicine(all)
  • Nutrition and Dietetics

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