Neurochemical and metabolic consequences of elevated cerebrospinal fluid quinolinic acid concentrations in rat brain

K. Maeda, H. Kaneda, W. O. Whetsell, C. A. Tamminga

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Quinolinic acid (QUIN) is an endogenous excitatory amino acid, which is elevated in brain tissues or cerebrospinal fluid (CSF) in several acute and chronic inflammatory central nervous system (CNS) diseases. The functional significance of this elevation is unknown but speculations of excitotoxicity have been raised. We have begun to address the pathologic consequences of elevated CSF QUIN by studying the effects of intracerebroventricular (icv) administration of QUIN on regional choline acetyltransferase (ChAT) activity, somatostatin content and glucose metabolism in the rat brain. QUIN (12 and 60 nmol) icv administration once a day for 7 days (total dose; 84 and 420 nmol, respectively) had minimal effect on somatostatin content and no effect on ChAT activity. In contrast, following continuous icv infusion of QUIN for 14 days using an osmotic minipump (480 nmol), ChAT activity dropped in the hippocampus and the striatum and somatostatin content was reduced in the frontal cortex, hippocampus, striatum and amygdala. Moreover, following the QUIN infusion, glucose utilization decreased in the basal nucleus of Meynert, frontal cortex, and portions of the basal ganglia and the limbic system. These results indicate that subchronic icv infusion of QUIN to rats results in selective regional neurochemical and metabolic changes distributed throughout the CNS. These results suggest target brain areas and transmitter systems which may be associated with neurologic syndromes characterized by elevated CSF QUIN levels.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalNeuroscience Research
Volume29
Issue number4
DOIs
StatePublished - Dec 1997

Fingerprint

Quinolinic Acid
Cerebrospinal Fluid
Brain
Choline O-Acetyltransferase
Somatostatin
Intraventricular Infusions
Frontal Lobe
Hippocampus
Basal Nucleus of Meynert
Glucose
Limbic System
Excitatory Amino Acids
Central Nervous System Diseases
Amygdala
Basal Ganglia
Nervous System
Central Nervous System

Keywords

  • 2-deoxyglucose
  • Cerebrospinal fluid
  • Choline acetyltransferase
  • Local cerebral glucose utilization
  • Quinolinic acid
  • Somatostatin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurochemical and metabolic consequences of elevated cerebrospinal fluid quinolinic acid concentrations in rat brain. / Maeda, K.; Kaneda, H.; Whetsell, W. O.; Tamminga, C. A.

In: Neuroscience Research, Vol. 29, No. 4, 12.1997, p. 303-309.

Research output: Contribution to journalArticle

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