Neurocognitive profile of an adult sample with chronic kidney disease

Sofia Śnchez-Roḿn, Feggy Ostrosky-Soĺs, Luis E. Morales-Buenrostro, M. G. Nogús-Vizcáno, Josefina Albeŕ, Shawn M. McClintock

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is a common and debilitating illness that impacts neurocognitive function. However, the majority of previous studies varied in methodologic design and rigor, thus minimizing definitive conclusions. The present study was designed to determine the impact of CKD on neurocognitive function through specific examination of CKD factors and therapeutic interventions. We evaluated 120 CKD outpatients and 41 healthy donors (controls) in terms of neurocognitive function, anxiety, and depressive symptomatology, and somnolence. Information regarding medical and treatment history was recorded. Twenty-three percent of CKD patients presented with cognitive impairment. Stage 5 patients had lower scores (p <.05) compared with controls and patients in stage 3 and 4 on measures of global cognitive function. No differences in global cognitive function were found between stage 3 and 4 patients and controls. A greater proportion of patients undergoing hemodialysis relative to those treated with peritoneal dialysis showed impairment on measures of memory functions. Results suggest that stage 5 CKD patients may present with impaired cognitive functions. Anemia appeared to be a key variable that may explain the memory impairment in this sample. Future longitudinal investigations of CKD are warranted to determine the trajectory of cognitive impairment. (JINS, 2010, 17,80-90)

Original languageEnglish (US)
Pages (from-to)80-90
Number of pages11
JournalJournal of the International Neuropsychological Society
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Chronic Renal Insufficiency
Disease
Cognition
Peritoneal Dialysis
Kidney
chronic illness
Renal Dialysis
Anemia
Outpatients
Anxiety
illness
History
Tissue Donors
anxiety
examination
Therapeutics
history
Cognitive Function

Keywords

  • Chronic kidney disease
  • Cognitive impairment
  • Hemodialysis
  • Memory
  • Neuropsychology
  • Peritoneal dialysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Language and Linguistics
  • Clinical Psychology
  • Linguistics and Language
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Śnchez-Roḿn, S., Ostrosky-Soĺs, F., Morales-Buenrostro, L. E., Nogús-Vizcáno, M. G., Albeŕ, J., & McClintock, S. M. (2011). Neurocognitive profile of an adult sample with chronic kidney disease. Journal of the International Neuropsychological Society, 17(1), 80-90. https://doi.org/10.1017/S1355617710001219

Neurocognitive profile of an adult sample with chronic kidney disease. / Śnchez-Roḿn, Sofia; Ostrosky-Soĺs, Feggy; Morales-Buenrostro, Luis E.; Nogús-Vizcáno, M. G.; Albeŕ, Josefina; McClintock, Shawn M.

In: Journal of the International Neuropsychological Society, Vol. 17, No. 1, 01.01.2011, p. 80-90.

Research output: Contribution to journalArticle

Śnchez-Roḿn, S, Ostrosky-Soĺs, F, Morales-Buenrostro, LE, Nogús-Vizcáno, MG, Albeŕ, J & McClintock, SM 2011, 'Neurocognitive profile of an adult sample with chronic kidney disease', Journal of the International Neuropsychological Society, vol. 17, no. 1, pp. 80-90. https://doi.org/10.1017/S1355617710001219
Śnchez-Roḿn, Sofia ; Ostrosky-Soĺs, Feggy ; Morales-Buenrostro, Luis E. ; Nogús-Vizcáno, M. G. ; Albeŕ, Josefina ; McClintock, Shawn M. / Neurocognitive profile of an adult sample with chronic kidney disease. In: Journal of the International Neuropsychological Society. 2011 ; Vol. 17, No. 1. pp. 80-90.
@article{86f255d5babf44ad9bdd2804b22f1d52,
title = "Neurocognitive profile of an adult sample with chronic kidney disease",
abstract = "Chronic kidney disease (CKD) is a common and debilitating illness that impacts neurocognitive function. However, the majority of previous studies varied in methodologic design and rigor, thus minimizing definitive conclusions. The present study was designed to determine the impact of CKD on neurocognitive function through specific examination of CKD factors and therapeutic interventions. We evaluated 120 CKD outpatients and 41 healthy donors (controls) in terms of neurocognitive function, anxiety, and depressive symptomatology, and somnolence. Information regarding medical and treatment history was recorded. Twenty-three percent of CKD patients presented with cognitive impairment. Stage 5 patients had lower scores (p <.05) compared with controls and patients in stage 3 and 4 on measures of global cognitive function. No differences in global cognitive function were found between stage 3 and 4 patients and controls. A greater proportion of patients undergoing hemodialysis relative to those treated with peritoneal dialysis showed impairment on measures of memory functions. Results suggest that stage 5 CKD patients may present with impaired cognitive functions. Anemia appeared to be a key variable that may explain the memory impairment in this sample. Future longitudinal investigations of CKD are warranted to determine the trajectory of cognitive impairment. (JINS, 2010, 17,80-90)",
keywords = "Chronic kidney disease, Cognitive impairment, Hemodialysis, Memory, Neuropsychology, Peritoneal dialysis",
author = "Sofia Śnchez-Roḿn and Feggy Ostrosky-Soĺs and Morales-Buenrostro, {Luis E.} and Nog{\'u}s-Vizc{\'a}no, {M. G.} and Josefina Albeŕ and McClintock, {Shawn M.}",
year = "2011",
month = "1",
day = "1",
doi = "10.1017/S1355617710001219",
language = "English (US)",
volume = "17",
pages = "80--90",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",
number = "1",

}

TY - JOUR

T1 - Neurocognitive profile of an adult sample with chronic kidney disease

AU - Śnchez-Roḿn, Sofia

AU - Ostrosky-Soĺs, Feggy

AU - Morales-Buenrostro, Luis E.

AU - Nogús-Vizcáno, M. G.

AU - Albeŕ, Josefina

AU - McClintock, Shawn M.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Chronic kidney disease (CKD) is a common and debilitating illness that impacts neurocognitive function. However, the majority of previous studies varied in methodologic design and rigor, thus minimizing definitive conclusions. The present study was designed to determine the impact of CKD on neurocognitive function through specific examination of CKD factors and therapeutic interventions. We evaluated 120 CKD outpatients and 41 healthy donors (controls) in terms of neurocognitive function, anxiety, and depressive symptomatology, and somnolence. Information regarding medical and treatment history was recorded. Twenty-three percent of CKD patients presented with cognitive impairment. Stage 5 patients had lower scores (p <.05) compared with controls and patients in stage 3 and 4 on measures of global cognitive function. No differences in global cognitive function were found between stage 3 and 4 patients and controls. A greater proportion of patients undergoing hemodialysis relative to those treated with peritoneal dialysis showed impairment on measures of memory functions. Results suggest that stage 5 CKD patients may present with impaired cognitive functions. Anemia appeared to be a key variable that may explain the memory impairment in this sample. Future longitudinal investigations of CKD are warranted to determine the trajectory of cognitive impairment. (JINS, 2010, 17,80-90)

AB - Chronic kidney disease (CKD) is a common and debilitating illness that impacts neurocognitive function. However, the majority of previous studies varied in methodologic design and rigor, thus minimizing definitive conclusions. The present study was designed to determine the impact of CKD on neurocognitive function through specific examination of CKD factors and therapeutic interventions. We evaluated 120 CKD outpatients and 41 healthy donors (controls) in terms of neurocognitive function, anxiety, and depressive symptomatology, and somnolence. Information regarding medical and treatment history was recorded. Twenty-three percent of CKD patients presented with cognitive impairment. Stage 5 patients had lower scores (p <.05) compared with controls and patients in stage 3 and 4 on measures of global cognitive function. No differences in global cognitive function were found between stage 3 and 4 patients and controls. A greater proportion of patients undergoing hemodialysis relative to those treated with peritoneal dialysis showed impairment on measures of memory functions. Results suggest that stage 5 CKD patients may present with impaired cognitive functions. Anemia appeared to be a key variable that may explain the memory impairment in this sample. Future longitudinal investigations of CKD are warranted to determine the trajectory of cognitive impairment. (JINS, 2010, 17,80-90)

KW - Chronic kidney disease

KW - Cognitive impairment

KW - Hemodialysis

KW - Memory

KW - Neuropsychology

KW - Peritoneal dialysis

UR - http://www.scopus.com/inward/record.url?scp=79451474400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79451474400&partnerID=8YFLogxK

U2 - 10.1017/S1355617710001219

DO - 10.1017/S1355617710001219

M3 - Article

VL - 17

SP - 80

EP - 90

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 1

ER -