Neurod1 is essential for the survival and maturation of adult-born neurons

Zhengliang Gao, Kerstin Ure, Jessica L. Ables, Diane C. Lagace, Klaus Armin Nave, Sandra Goebbels, Amelia J Eisch, Jenny Hsieh

Research output: Contribution to journalArticle

237 Scopus citations

Abstract

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

Original languageEnglish (US)
Pages (from-to)1090-1092
Number of pages3
JournalNature neuroscience
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2009

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gao, Z., Ure, K., Ables, J. L., Lagace, D. C., Nave, K. A., Goebbels, S., Eisch, A. J., & Hsieh, J. (2009). Neurod1 is essential for the survival and maturation of adult-born neurons. Nature neuroscience, 12(9), 1090-1092. https://doi.org/10.1038/nn.2385