Neurod1 is essential for the survival and maturation of adult-born neurons

Zhengliang Gao, Kerstin Ure, Jessica L. Ables, Diane C. Lagace, Klaus Armin Nave, Sandra Goebbels, Amelia J Eisch, Jenny Hsieh

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226 Citations (Scopus)

Abstract

The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.

Original languageEnglish (US)
Pages (from-to)1090-1092
Number of pages3
JournalNature Neuroscience
Volume12
Issue number9
DOIs
StatePublished - Sep 2009

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Neurons
Olfactory Bulb
Neurogenesis
Hippocampus
Stem Cells

ASJC Scopus subject areas

  • Neuroscience(all)

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Gao, Z., Ure, K., Ables, J. L., Lagace, D. C., Nave, K. A., Goebbels, S., ... Hsieh, J. (2009). Neurod1 is essential for the survival and maturation of adult-born neurons. Nature Neuroscience, 12(9), 1090-1092. https://doi.org/10.1038/nn.2385

Neurod1 is essential for the survival and maturation of adult-born neurons. / Gao, Zhengliang; Ure, Kerstin; Ables, Jessica L.; Lagace, Diane C.; Nave, Klaus Armin; Goebbels, Sandra; Eisch, Amelia J; Hsieh, Jenny.

In: Nature Neuroscience, Vol. 12, No. 9, 09.2009, p. 1090-1092.

Research output: Contribution to journalArticle

Gao, Z, Ure, K, Ables, JL, Lagace, DC, Nave, KA, Goebbels, S, Eisch, AJ & Hsieh, J 2009, 'Neurod1 is essential for the survival and maturation of adult-born neurons', Nature Neuroscience, vol. 12, no. 9, pp. 1090-1092. https://doi.org/10.1038/nn.2385
Gao Z, Ure K, Ables JL, Lagace DC, Nave KA, Goebbels S et al. Neurod1 is essential for the survival and maturation of adult-born neurons. Nature Neuroscience. 2009 Sep;12(9):1090-1092. https://doi.org/10.1038/nn.2385
Gao, Zhengliang ; Ure, Kerstin ; Ables, Jessica L. ; Lagace, Diane C. ; Nave, Klaus Armin ; Goebbels, Sandra ; Eisch, Amelia J ; Hsieh, Jenny. / Neurod1 is essential for the survival and maturation of adult-born neurons. In: Nature Neuroscience. 2009 ; Vol. 12, No. 9. pp. 1090-1092.
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