Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III

L. F. Chalak, T. L. Dupont, P. J. Sánchez, A. Lucke, R. J. Heyne, M. C. Morriss, N. K. Rollins

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective:Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.Study Design:We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005-November 2011.Result:Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50%, while Bayley III <70 occurred in 13%. MRI predicted Bayley III<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.Conclusion:A Bayley-III 85 cutoff identifies a disability rate of 50%, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalJournal of Perinatology
Volume34
Issue number8
DOIs
StatePublished - 2014

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Hypothermia
Magnetic Resonance Imaging
Incidence
Family Planning Services
Brain Diseases
Therapeutics
Counseling
Cohort Studies
Newborn Infant
Prospective Studies
Sensitivity and Specificity
Population

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

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Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III. / Chalak, L. F.; Dupont, T. L.; Sánchez, P. J.; Lucke, A.; Heyne, R. J.; Morriss, M. C.; Rollins, N. K.

In: Journal of Perinatology, Vol. 34, No. 8, 2014, p. 629-633.

Research output: Contribution to journalArticle

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abstract = "Objective:Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.Study Design:We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005-November 2011.Result:Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89{\%} had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50{\%}, while Bayley III <70 occurred in 13{\%}. MRI predicted Bayley III<85 with sensitivity of 73{\%}, specificity of 84{\%}, positive-predictive value of 84{\%} and negative-predictive value of 74{\%}.Conclusion:A Bayley-III 85 cutoff identifies a disability rate of 50{\%}, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.",
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AU - Chalak, L. F.

AU - Dupont, T. L.

AU - Sánchez, P. J.

AU - Lucke, A.

AU - Heyne, R. J.

AU - Morriss, M. C.

AU - Rollins, N. K.

PY - 2014

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N2 - Objective:Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.Study Design:We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005-November 2011.Result:Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50%, while Bayley III <70 occurred in 13%. MRI predicted Bayley III<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.Conclusion:A Bayley-III 85 cutoff identifies a disability rate of 50%, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.

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