Neurofibromatosis and pregnancy: A report of maternal cardiopulmonary compromise

David B. Nelson, Laura Greer, George Wendel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Neurofibromatosis is a rare pregnancy complication that can present with rapidly enlarging masses that have malignant potential. Case: A 19-year-old primagravid woman with a known history of neurofibromatosis presented in her first trimester with pulmonary complaints. A malignant mediastinal mass was diagnosed and resected, with additional treatment options declined. In less than 3 months, the patient presented with a recurrent mass that resulted in fatal airway compromise during the same gestation. Conclusion: Neurofibromatosis type 1 with malignant peripheral nerve sheath tumors complicating pregnancy requires an experienced, multidisciplinary team of care offering an aggressive evaluation to rule out malignant transformation or recurrence when there is any change in clinical status of a patient, as this may signal a potentially fatal change in the lesion.

Original languageEnglish (US)
Pages (from-to)507-509
Number of pages3
JournalObstetrics and Gynecology
Volume116
Issue number2 PART 2
DOIs
StatePublished - Aug 2010

Fingerprint

Neurofibromatoses
Mothers
Pregnancy
Neurofibromatosis 1
Pregnancy Complications
Neurilemmoma
First Pregnancy Trimester
Recurrence
Lung
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Neurofibromatosis and pregnancy : A report of maternal cardiopulmonary compromise. / Nelson, David B.; Greer, Laura; Wendel, George.

In: Obstetrics and Gynecology, Vol. 116, No. 2 PART 2, 08.2010, p. 507-509.

Research output: Contribution to journalArticle

Nelson, David B. ; Greer, Laura ; Wendel, George. / Neurofibromatosis and pregnancy : A report of maternal cardiopulmonary compromise. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 2 PART 2. pp. 507-509.
@article{15244d31cf3949d980bbc5e08f47eb76,
title = "Neurofibromatosis and pregnancy: A report of maternal cardiopulmonary compromise",
abstract = "Background: Neurofibromatosis is a rare pregnancy complication that can present with rapidly enlarging masses that have malignant potential. Case: A 19-year-old primagravid woman with a known history of neurofibromatosis presented in her first trimester with pulmonary complaints. A malignant mediastinal mass was diagnosed and resected, with additional treatment options declined. In less than 3 months, the patient presented with a recurrent mass that resulted in fatal airway compromise during the same gestation. Conclusion: Neurofibromatosis type 1 with malignant peripheral nerve sheath tumors complicating pregnancy requires an experienced, multidisciplinary team of care offering an aggressive evaluation to rule out malignant transformation or recurrence when there is any change in clinical status of a patient, as this may signal a potentially fatal change in the lesion.",
author = "Nelson, {David B.} and Laura Greer and George Wendel",
year = "2010",
month = "8",
doi = "10.1097/AOG.0b013e3181da0113",
language = "English (US)",
volume = "116",
pages = "507--509",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "2 PART 2",

}

TY - JOUR

T1 - Neurofibromatosis and pregnancy

T2 - A report of maternal cardiopulmonary compromise

AU - Nelson, David B.

AU - Greer, Laura

AU - Wendel, George

PY - 2010/8

Y1 - 2010/8

N2 - Background: Neurofibromatosis is a rare pregnancy complication that can present with rapidly enlarging masses that have malignant potential. Case: A 19-year-old primagravid woman with a known history of neurofibromatosis presented in her first trimester with pulmonary complaints. A malignant mediastinal mass was diagnosed and resected, with additional treatment options declined. In less than 3 months, the patient presented with a recurrent mass that resulted in fatal airway compromise during the same gestation. Conclusion: Neurofibromatosis type 1 with malignant peripheral nerve sheath tumors complicating pregnancy requires an experienced, multidisciplinary team of care offering an aggressive evaluation to rule out malignant transformation or recurrence when there is any change in clinical status of a patient, as this may signal a potentially fatal change in the lesion.

AB - Background: Neurofibromatosis is a rare pregnancy complication that can present with rapidly enlarging masses that have malignant potential. Case: A 19-year-old primagravid woman with a known history of neurofibromatosis presented in her first trimester with pulmonary complaints. A malignant mediastinal mass was diagnosed and resected, with additional treatment options declined. In less than 3 months, the patient presented with a recurrent mass that resulted in fatal airway compromise during the same gestation. Conclusion: Neurofibromatosis type 1 with malignant peripheral nerve sheath tumors complicating pregnancy requires an experienced, multidisciplinary team of care offering an aggressive evaluation to rule out malignant transformation or recurrence when there is any change in clinical status of a patient, as this may signal a potentially fatal change in the lesion.

UR - http://www.scopus.com/inward/record.url?scp=77955164769&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955164769&partnerID=8YFLogxK

U2 - 10.1097/AOG.0b013e3181da0113

DO - 10.1097/AOG.0b013e3181da0113

M3 - Article

C2 - 20664435

AN - SCOPUS:77955164769

VL - 116

SP - 507

EP - 509

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 2 PART 2

ER -