Neuroneogenese. Relevanz für pathophysiologie und pharmakotherapie psychiatrischer erkrankungen

Translated title of the contribution: Neurogenesis. Relevance to pathophysiology and pharmacotherapy of psychiatric disorders

J. Thome, A. J. Eisch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Research into neurogenesis, i.e., the growth of new neurons in the adult brain, is leaving the area of pure basic science and gaining relevance for clinical disciplines such as psychopharmacology and molecular psychiatry. Neurogenesis is proposed to play a crucial role in psychiatric disorders which exhibit degenerative alterations, neural maldevelopment, and changes in neural plasticity as potentially important pathophysiological factors. Especially in dementia, drug addiction, and schizophrenic and affective psychoses, disruption of adult neurogenesis could thus represent a considerable pathogenetic element. Interestingly, several psychotropic drugs (e.g., antidepressants, atypical antipsychotics) are able to modify neurogenesis significantly. Further elucidation of the importance and implications of neurogenesis may concomitantly result in better understanding of the etiopathogenesis of mental disorders and increased knowledge of the mechanisms of action of psychotropic substances. Furthermore, this may support the development of promising innovative therapeutic approaches in clinical practice.

Original languageGerman
Pages (from-to)11-19
Number of pages9
JournalNervenarzt
Volume76
Issue number1
DOIs
StatePublished - Jan 2005

Fingerprint

Neurogenesis
Psychiatry
Drug Therapy
Second-Generation Antidepressive Agents
Psychotic Affective Disorders
Psychopharmacology
Neuronal Plasticity
Psychotropic Drugs
Mental Disorders
Antipsychotic Agents
Substance-Related Disorders
Dementia
Neurons
Brain
Growth
Research

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health

Cite this

Neuroneogenese. Relevanz für pathophysiologie und pharmakotherapie psychiatrischer erkrankungen. / Thome, J.; Eisch, A. J.

In: Nervenarzt, Vol. 76, No. 1, 01.2005, p. 11-19.

Research output: Contribution to journalArticle

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