Neuroimaging evolution of ischemia in men and women

an observational study

the LESION Investigators

Research output: Contribution to journalArticle

Abstract

Objective: We present an exploratory study for identification of sex differences in imaging biomarkers that could further refine selection of patients for acute reperfusion therapy and trials based on sex and imaging targets. Methods: The Lesion Evolution in Stroke and Ischemia On Neuroimaging (LESION) study included consecutive acute stroke patients who underwent MRI within 24 h of time from last known well and prior to therapy. Those demonstrating a potential therapeutic target on imaging were identified by presence of: (1) arterial occlusion on angiography, (2) focal ischemic region on perfusion maps, or (3) a mismatch of perfusion versus diffusion imaging lesion size. The prevalence of imaging targets within clinically relevant time intervals was calculated for each patient and examined. The relationship of time from stroke onset to probability of detection of imaging targets was evaluated. Results: Of 7007 patients screened, of which 86.7% were scanned with MRI, 1092 patients (477/615 men/women) were included in LESION. The probability of imaging target detection was significantly different between men and women, with women more likely to present with all assessed imaging targets, odds ratios between 1.36 and 1.59, P < 0.02, adjusted for NIHSS, age, and time from last known well to MRI scan. This trend held for the entire 24-h studied. Interpretation: Women present more often with treatable ischemic stroke than men. The greater probability of potentially viable and/or treatable imaging targets in women at all time points suggests that tissue injury is slower to evolve in women.

Original languageEnglish (US)
Pages (from-to)575-585
Number of pages11
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number3
DOIs
StatePublished - Mar 1 2019

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Neuroimaging
Observational Studies
Ischemia
Stroke
Perfusion
Sex Characteristics
Patient Selection
Reperfusion
Angiography
Therapeutics
Biomarkers
Odds Ratio
Magnetic Resonance Imaging
Wounds and Injuries

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Neuroimaging evolution of ischemia in men and women : an observational study. / the LESION Investigators.

In: Annals of Clinical and Translational Neurology, Vol. 6, No. 3, 01.03.2019, p. 575-585.

Research output: Contribution to journalArticle

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abstract = "Objective: We present an exploratory study for identification of sex differences in imaging biomarkers that could further refine selection of patients for acute reperfusion therapy and trials based on sex and imaging targets. Methods: The Lesion Evolution in Stroke and Ischemia On Neuroimaging (LESION) study included consecutive acute stroke patients who underwent MRI within 24 h of time from last known well and prior to therapy. Those demonstrating a potential therapeutic target on imaging were identified by presence of: (1) arterial occlusion on angiography, (2) focal ischemic region on perfusion maps, or (3) a mismatch of perfusion versus diffusion imaging lesion size. The prevalence of imaging targets within clinically relevant time intervals was calculated for each patient and examined. The relationship of time from stroke onset to probability of detection of imaging targets was evaluated. Results: Of 7007 patients screened, of which 86.7{\%} were scanned with MRI, 1092 patients (477/615 men/women) were included in LESION. The probability of imaging target detection was significantly different between men and women, with women more likely to present with all assessed imaging targets, odds ratios between 1.36 and 1.59, P < 0.02, adjusted for NIHSS, age, and time from last known well to MRI scan. This trend held for the entire 24-h studied. Interpretation: Women present more often with treatable ischemic stroke than men. The greater probability of potentially viable and/or treatable imaging targets in women at all time points suggests that tissue injury is slower to evolve in women.",
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AU - Sheth, Sunil A.

AU - Magadan, Alejandro

AU - Davis, Lisa A.

AU - Gealogo, Gretchel A.

AU - Merino, José G.

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AU - Latour, Lawrence L.

AU - Warach, Steven J.

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