Neuroimmune disorders of the central nervous system in children in the molecular era

Elizabeth Wells, Yael Hacohen, Amy Waldman, Jan M. Tillema, Ariane Soldatos, Beau Ances, Susanne Benseler, Bibi Bielekova, Russel C. Dale, Josep Dalmau, William Gaillard, Mark Gorman, Benjamin Greenberg, Ann Hyslop, Carlos A. Pardo, Robert C. Tasker, E. Ann Yeh, Amit Bar-Or, Sean Pittock, Adeline VanderverBrenda Banwell

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Immune-mediated disorders of the CNS in children are a complex group of demyelinating, inflammatory, parainfectious and postinfectious disorders with heterogeneous pathobiological mechanisms and clinical manifestations, often associated with fundamental derangement in immune regulation. In this Review, we aim to provide an update on our knowledge of neuroimmune disorders and highlight areas of research that are priorities for improving clinical management. We outline the clinical features of neuroimmune disorders, the current approaches to their treatment and new approaches in development. We then consider the pathological features, including biomarkers, pathological mechanisms and genetics, and discuss the value of immune assays in clinical investigation and basic research. On the basis of current knowledge and techniques, we propose four research priorities: Rigorous and consistent collection of core clinical data, cooperative investigation of treatments, development of biological assays and genetic studies. These priorities should help us to achieve the shared goal of precision medicine for neuroimmune disorders. However, multicentre research and the creation of clinical consortia for these rare disorders will be necessary, and we hope that this Review serves as a call to action that is timely given current exciting advances in neuroimmune therapeutics.

Original languageEnglish (US)
Pages (from-to)433-445
Number of pages13
JournalNature Reviews Neurology
Volume14
Issue number7
DOIs
StatePublished - Jul 1 2018

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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