TY - JOUR
T1 - Neurologic and developmental status related to the evolution of visual-motor abnormalities from birth to 2 years of age in preterm infants with intraventricular hemorrhage
AU - Vohr, Betty R.
AU - Garcia-Coll, Cynthia
AU - Mayfield, Steven
AU - Brann, Benjamin
AU - Shaul, Philip
AU - Oh, William
N1 - Funding Information:
Very low birth weight infants (birth weights __<1500 gm) are at significant risk for intraventricular hemorrhage because of the vascular state of their germinal matrix. 1 The improved survival rate of very low birth weight infants, 2,3 in conjunction with increased ease in identification of IVH by ultrasonography, 5 has resulted in multiple studies assessing the neurodevelopmental outcome of infants with IVH. 6-9 Papile et al. 7 and Krishnamoorthy et al. 6 identified Supported by March of Dimes grant No. 12-204. Submitted for publication Dec. 5, 1988; accepted March 3, 1989. Reprint requests: Betty V. Vohr, MD, Director, Neonatal Follow-up Clinic, Women and Infants Hospital of Rhode Island, 101 Dudley St., Providence, RI 02905-2499.
PY - 1989/8
Y1 - 1989/8
N2 - We prospectively and longitudinally evaluated neurologic status, cognitive status, and visual-evoked responses in 63 premature infants with cerebral intraventricular hemorrhage, 27 premature infants without hemorrhage, and 22 full-term normal infants. We hypothesized that severe intraventricular hemorrhage (grades III and IV) is associated with impaired visual-motor function, in part because of compression-related injury of the periventricular white matter by ventricular dilation. Infants with grade III or IV hemorrhage had significantly more neurologic sequelae at term and at 3, 7, 12, and 24 months; lower Bayley mental and motor scores at 3, 7, and 12 months; more abnormality on Kohen-Raz subscales for eye-hand coordination, object manipulation, and object relations at 3, 7, and 12 months; and lower Mullen vision-receptive and vision-expressive coordination scores at 24 months. The 12-month visual-evoked response correlated with the 24-month vision-receptive and vision-expressive organization scores for infants with grade III or IV intraventricular hemorrhage (r=-0.49, p<0.01, and r=-0.40, p<0.05, respectively). The data confirm our hypotheses of increased cognitive and neurologic sequelae, and increased abnormality of visual-motor coordination, during the first 2 years of life in infants with severe (grade III or IV) intraventricular hemorrhage.
AB - We prospectively and longitudinally evaluated neurologic status, cognitive status, and visual-evoked responses in 63 premature infants with cerebral intraventricular hemorrhage, 27 premature infants without hemorrhage, and 22 full-term normal infants. We hypothesized that severe intraventricular hemorrhage (grades III and IV) is associated with impaired visual-motor function, in part because of compression-related injury of the periventricular white matter by ventricular dilation. Infants with grade III or IV hemorrhage had significantly more neurologic sequelae at term and at 3, 7, 12, and 24 months; lower Bayley mental and motor scores at 3, 7, and 12 months; more abnormality on Kohen-Raz subscales for eye-hand coordination, object manipulation, and object relations at 3, 7, and 12 months; and lower Mullen vision-receptive and vision-expressive coordination scores at 24 months. The 12-month visual-evoked response correlated with the 24-month vision-receptive and vision-expressive organization scores for infants with grade III or IV intraventricular hemorrhage (r=-0.49, p<0.01, and r=-0.40, p<0.05, respectively). The data confirm our hypotheses of increased cognitive and neurologic sequelae, and increased abnormality of visual-motor coordination, during the first 2 years of life in infants with severe (grade III or IV) intraventricular hemorrhage.
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U2 - 10.1016/S0022-3476(89)80089-7
DO - 10.1016/S0022-3476(89)80089-7
M3 - Article
C2 - 2474065
AN - SCOPUS:0024334945
SN - 0022-3476
VL - 115
SP - 296
EP - 302
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 2
ER -