Neurologic complications of bone marrow transplantation

R. A. Patchell, C. L. White, A. W. Clark, W. E. Beschorner, G. W. Santos

Research output: Contribution to journalArticlepeer-review

130 Scopus citations

Abstract

Among 78 patients who died after bone marrow transplantation, neurologic complications were present in 55 (70%) and were the cause of death in 5 (6%). Metabolic encephalopathy occurred in 29 patients (37%). CNS infections included aspergillosis (3), herpes simplex encephalitis (2), and Listeria monocytogenes meningitis (1). Six additional patients had neuropathologic changes possibly due to cytomegalovirus infection. Cerebrovascular complications occurred in five patients (two hemorrhages and three infarcts). All infarcts were associated with endocarditis. The rate of nonbacterial thrombotic endocarditis was significantly higher (p < 0.001) than in the general autopsy population. CNS leukemia and therapy-induced injury were rare. There was no evidence of graft-versus-host disease involving the CNS.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalNeurology
Volume35
Issue number3
DOIs
StatePublished - Mar 1985

ASJC Scopus subject areas

  • Clinical Neurology

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