TY - JOUR
T1 - Neurologic manifestations of Whipple's disease
AU - Lugassy, Mara M.
AU - Louis, Elan D.
PY - 2006/7
Y1 - 2006/7
N2 - Whipple's disease is a rare, multisystem, infectious disorder caused by the bacterium Tropheryma whippelii. Patients with central nervous system (CNS) involvement may present in a variety of ways, including cognitive impairment, psychiatric manifestations, gaze palsies, upper motor neuron signs, and hypothalamic dysfunction. A tissue-based diagnosis of Whipple's disease is made based on the presence of periodic acid - Schiff-stained material or by the identification of bacterial RNA using polymerase chain reaction. To avoid relapse, patients should be treated with antimicrobial agents that penetrate the CNS, and therapy should be continued for at least 1 year.
AB - Whipple's disease is a rare, multisystem, infectious disorder caused by the bacterium Tropheryma whippelii. Patients with central nervous system (CNS) involvement may present in a variety of ways, including cognitive impairment, psychiatric manifestations, gaze palsies, upper motor neuron signs, and hypothalamic dysfunction. A tissue-based diagnosis of Whipple's disease is made based on the presence of periodic acid - Schiff-stained material or by the identification of bacterial RNA using polymerase chain reaction. To avoid relapse, patients should be treated with antimicrobial agents that penetrate the CNS, and therapy should be continued for at least 1 year.
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U2 - 10.1007/s11908-006-0075-8
DO - 10.1007/s11908-006-0075-8
M3 - Review article
C2 - 16822374
AN - SCOPUS:33746087628
SN - 1523-3847
VL - 8
SP - 301
EP - 306
JO - Current Infectious Disease Reports
JF - Current Infectious Disease Reports
IS - 4
ER -