Neurological autoimmune disorders with prominent gastrointestinal manifestations: A review of presentation, evaluation, and treatment

Kyle M. Blackburn, Maddie Kubiliun, Samar Harris, Steven Vernino

Research output: Contribution to journalReview article

Abstract

Background: The identification of autoantibodies directed against neuronal antigens has led to the recognition of a wide spectrum of neurological autoimmune disorders (NAD). With timely recognition and treatment, many patients with NAD see rapid improvement. Symptoms associated with NAD can be diverse and are determined by the regions of the nervous system affected. In addition to neurological symptoms, a number of these disorders present with prominent gastrointestinal (GI) manifestations such as nausea, diarrhea, weight loss, and gastroparesis prompting an initial evaluation by gastroenterologists. Purpose: This review provides a general overview of autoantibodies within the nervous system, focusing on three scenarios in which nervous system autoimmunity may initially present with gut symptoms. A general approach to evaluation and treatment, including antibody testing, will be reviewed.

Original languageEnglish (US)
Article numbere13611
JournalNeurogastroenterology and Motility
DOIs
StatePublished - Jan 1 2019

Keywords

  • autoimmune disease
  • autonomic neuropathy
  • chronic nausea and vomiting
  • paraneoplastic

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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