Neurological autoimmune disorders with prominent gastrointestinal manifestations: A review of presentation, evaluation, and treatment

Kyle M. Blackburn, Maddie Kubiliun, Samar Harris, Steven Vernino

Research output: Contribution to journalReview article

Abstract

Background: The identification of autoantibodies directed against neuronal antigens has led to the recognition of a wide spectrum of neurological autoimmune disorders (NAD). With timely recognition and treatment, many patients with NAD see rapid improvement. Symptoms associated with NAD can be diverse and are determined by the regions of the nervous system affected. In addition to neurological symptoms, a number of these disorders present with prominent gastrointestinal (GI) manifestations such as nausea, diarrhea, weight loss, and gastroparesis prompting an initial evaluation by gastroenterologists. Purpose: This review provides a general overview of autoantibodies within the nervous system, focusing on three scenarios in which nervous system autoimmunity may initially present with gut symptoms. A general approach to evaluation and treatment, including antibody testing, will be reviewed.

Original languageEnglish (US)
Article numbere13611
JournalNeurogastroenterology and Motility
DOIs
StatePublished - Jan 1 2019

Fingerprint

Nervous System Diseases
Nervous System
Autoantibodies
Gastroparesis
Autoimmunity
Nausea
Weight Loss
Diarrhea
Therapeutics
Antigens
Antibodies

Keywords

  • autoimmune disease
  • autonomic neuropathy
  • chronic nausea and vomiting
  • paraneoplastic

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

@article{d4cb5ae5c69944059e1747dbcb9310d5,
title = "Neurological autoimmune disorders with prominent gastrointestinal manifestations: A review of presentation, evaluation, and treatment",
abstract = "Background: The identification of autoantibodies directed against neuronal antigens has led to the recognition of a wide spectrum of neurological autoimmune disorders (NAD). With timely recognition and treatment, many patients with NAD see rapid improvement. Symptoms associated with NAD can be diverse and are determined by the regions of the nervous system affected. In addition to neurological symptoms, a number of these disorders present with prominent gastrointestinal (GI) manifestations such as nausea, diarrhea, weight loss, and gastroparesis prompting an initial evaluation by gastroenterologists. Purpose: This review provides a general overview of autoantibodies within the nervous system, focusing on three scenarios in which nervous system autoimmunity may initially present with gut symptoms. A general approach to evaluation and treatment, including antibody testing, will be reviewed.",
keywords = "autoimmune disease, autonomic neuropathy, chronic nausea and vomiting, paraneoplastic",
author = "Blackburn, {Kyle M.} and Maddie Kubiliun and Samar Harris and Steven Vernino",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/nmo.13611",
language = "English (US)",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Neurological autoimmune disorders with prominent gastrointestinal manifestations

T2 - A review of presentation, evaluation, and treatment

AU - Blackburn, Kyle M.

AU - Kubiliun, Maddie

AU - Harris, Samar

AU - Vernino, Steven

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The identification of autoantibodies directed against neuronal antigens has led to the recognition of a wide spectrum of neurological autoimmune disorders (NAD). With timely recognition and treatment, many patients with NAD see rapid improvement. Symptoms associated with NAD can be diverse and are determined by the regions of the nervous system affected. In addition to neurological symptoms, a number of these disorders present with prominent gastrointestinal (GI) manifestations such as nausea, diarrhea, weight loss, and gastroparesis prompting an initial evaluation by gastroenterologists. Purpose: This review provides a general overview of autoantibodies within the nervous system, focusing on three scenarios in which nervous system autoimmunity may initially present with gut symptoms. A general approach to evaluation and treatment, including antibody testing, will be reviewed.

AB - Background: The identification of autoantibodies directed against neuronal antigens has led to the recognition of a wide spectrum of neurological autoimmune disorders (NAD). With timely recognition and treatment, many patients with NAD see rapid improvement. Symptoms associated with NAD can be diverse and are determined by the regions of the nervous system affected. In addition to neurological symptoms, a number of these disorders present with prominent gastrointestinal (GI) manifestations such as nausea, diarrhea, weight loss, and gastroparesis prompting an initial evaluation by gastroenterologists. Purpose: This review provides a general overview of autoantibodies within the nervous system, focusing on three scenarios in which nervous system autoimmunity may initially present with gut symptoms. A general approach to evaluation and treatment, including antibody testing, will be reviewed.

KW - autoimmune disease

KW - autonomic neuropathy

KW - chronic nausea and vomiting

KW - paraneoplastic

UR - http://www.scopus.com/inward/record.url?scp=85064621901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064621901&partnerID=8YFLogxK

U2 - 10.1111/nmo.13611

DO - 10.1111/nmo.13611

M3 - Review article

C2 - 31016817

AN - SCOPUS:85064621901

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

M1 - e13611

ER -