Neurological emergencies associated with COVID-19: stroke and beyond

Amit Agarwal, Marco Pinho, Karuna Raj, Frank F. Yu, Girish Bathla, Michael Achilleos, Thomas ONeill, Michael Still, Joseph Maldjian

Research output: Contribution to journalArticle


Novel coronavirus disease (COVID-19) was declared a global pandemic on March 1, 2020. Neurological manifestations are now being reported worldwide, including emergent presentation with acute neurological changes as well as a comorbidity in hospitalized patients. There is limited knowledge on the neurologic manifestations of COVID-19 at present, with a wide array of neurological complications reported, ranging from ischemic stroke to acute demyelination and encephalitis. We report five cases of COVID-19 presenting to the ER with acute neurological symptoms, over the course of 1 month. This includes two cases of ischemic stroke, one with large-vessel occlusion and one with embolic infarcts. The remainders of the cases include acute tumefactive demyelination, isolated cytotoxic edema of the corpus callosum with subarachnoid hemorrhage, and posterior reversible encephalopathy syndrome (PRES).

Original languageEnglish (US)
JournalEmergency Radiology
StateAccepted/In press - 2020


  • COVID-19
  • Hypercoagulable
  • MRI
  • Neurological
  • Neurotropism

ASJC Scopus subject areas

  • Emergency Medicine
  • Radiology Nuclear Medicine and imaging

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