Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography

J. L. Bennett, J. De Seze, M. Lana-Peixoto, J. Palace, A. Waldman, S. Schippling, S. Tenembaum, B. Banwell, B. Greenberg, M. Levy, K. Fujihara, K. H. Chan, H. J. Kim, N. Asgari, D. K. Sato, A. Saiz, J. Wuerfel, H. Zimmermann, A. Green, P. VillosladaF. Paul

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients' RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

Original languageEnglish (US)
Pages (from-to)678-688
Number of pages11
JournalMultiple Sclerosis
Volume21
Issue number6
DOIs
StatePublished - May 4 2015

Fingerprint

Neuromyelitis Optica
Optical Coherence Tomography
Multiple Sclerosis
Optic Neuritis
Nerve Fibers
Autoimmune Diseases of the Nervous System
Aquaporin 4
Aquaporins
Macular Edema
Optic Nerve
Ganglia
Autoantibodies
Spinal Cord
Central Nervous System
Serum

Keywords

  • ganglion cell layer
  • multiple sclerosis
  • Neuromyelitis optica
  • optic neuritis
  • optical coherence tomography
  • retinal nerve fiber layer

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Bennett, J. L., De Seze, J., Lana-Peixoto, M., Palace, J., Waldman, A., Schippling, S., ... Paul, F. (2015). Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Multiple Sclerosis, 21(6), 678-688. https://doi.org/10.1177/1352458514567216

Neuromyelitis optica and multiple sclerosis : Seeing differences through optical coherence tomography. / Bennett, J. L.; De Seze, J.; Lana-Peixoto, M.; Palace, J.; Waldman, A.; Schippling, S.; Tenembaum, S.; Banwell, B.; Greenberg, B.; Levy, M.; Fujihara, K.; Chan, K. H.; Kim, H. J.; Asgari, N.; Sato, D. K.; Saiz, A.; Wuerfel, J.; Zimmermann, H.; Green, A.; Villoslada, P.; Paul, F.

In: Multiple Sclerosis, Vol. 21, No. 6, 04.05.2015, p. 678-688.

Research output: Contribution to journalArticle

Bennett, JL, De Seze, J, Lana-Peixoto, M, Palace, J, Waldman, A, Schippling, S, Tenembaum, S, Banwell, B, Greenberg, B, Levy, M, Fujihara, K, Chan, KH, Kim, HJ, Asgari, N, Sato, DK, Saiz, A, Wuerfel, J, Zimmermann, H, Green, A, Villoslada, P & Paul, F 2015, 'Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography', Multiple Sclerosis, vol. 21, no. 6, pp. 678-688. https://doi.org/10.1177/1352458514567216
Bennett JL, De Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S et al. Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Multiple Sclerosis. 2015 May 4;21(6):678-688. https://doi.org/10.1177/1352458514567216
Bennett, J. L. ; De Seze, J. ; Lana-Peixoto, M. ; Palace, J. ; Waldman, A. ; Schippling, S. ; Tenembaum, S. ; Banwell, B. ; Greenberg, B. ; Levy, M. ; Fujihara, K. ; Chan, K. H. ; Kim, H. J. ; Asgari, N. ; Sato, D. K. ; Saiz, A. ; Wuerfel, J. ; Zimmermann, H. ; Green, A. ; Villoslada, P. ; Paul, F. / Neuromyelitis optica and multiple sclerosis : Seeing differences through optical coherence tomography. In: Multiple Sclerosis. 2015 ; Vol. 21, No. 6. pp. 678-688.
@article{b8680679cdac41c7a836e54ac2af4133,
title = "Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography",
abstract = "Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80{\%} of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients' RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.",
keywords = "ganglion cell layer, multiple sclerosis, Neuromyelitis optica, optic neuritis, optical coherence tomography, retinal nerve fiber layer",
author = "Bennett, {J. L.} and {De Seze}, J. and M. Lana-Peixoto and J. Palace and A. Waldman and S. Schippling and S. Tenembaum and B. Banwell and B. Greenberg and M. Levy and K. Fujihara and Chan, {K. H.} and Kim, {H. J.} and N. Asgari and Sato, {D. K.} and A. Saiz and J. Wuerfel and H. Zimmermann and A. Green and P. Villoslada and F. Paul",
year = "2015",
month = "5",
day = "4",
doi = "10.1177/1352458514567216",
language = "English (US)",
volume = "21",
pages = "678--688",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "6",

}

TY - JOUR

T1 - Neuromyelitis optica and multiple sclerosis

T2 - Seeing differences through optical coherence tomography

AU - Bennett, J. L.

AU - De Seze, J.

AU - Lana-Peixoto, M.

AU - Palace, J.

AU - Waldman, A.

AU - Schippling, S.

AU - Tenembaum, S.

AU - Banwell, B.

AU - Greenberg, B.

AU - Levy, M.

AU - Fujihara, K.

AU - Chan, K. H.

AU - Kim, H. J.

AU - Asgari, N.

AU - Sato, D. K.

AU - Saiz, A.

AU - Wuerfel, J.

AU - Zimmermann, H.

AU - Green, A.

AU - Villoslada, P.

AU - Paul, F.

PY - 2015/5/4

Y1 - 2015/5/4

N2 - Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients' RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

AB - Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients' RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.

KW - ganglion cell layer

KW - multiple sclerosis

KW - Neuromyelitis optica

KW - optic neuritis

KW - optical coherence tomography

KW - retinal nerve fiber layer

UR - http://www.scopus.com/inward/record.url?scp=84961289267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961289267&partnerID=8YFLogxK

U2 - 10.1177/1352458514567216

DO - 10.1177/1352458514567216

M3 - Article

C2 - 25662342

AN - SCOPUS:84961289267

VL - 21

SP - 678

EP - 688

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 6

ER -