TY - JOUR
T1 - Neuromyelitis optica spectrum disorder associated with autoimmune hemolytic anemia and lymphoma
AU - Wang, Yujie
AU - Miocinovic, Svjetlana
AU - Greenberg, Benjamin M.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder characterized by monophasic or recurrent attacks of optic neuritis (ON) and transverse myelitis. NMO spectrum disorders include patients who are seropositive for NMO-IgG antibody and have experienced at least 1 demyelinating attack. NMO has been associated with other autoimmune conditions. We describe a patient diagnosed with autoimmune hemolytic anemia and marginal zone lymphoma, who later developed NMO-IgG seropositive ON. The coexistence of multiple immunologic abnormalities in this patient points to a generalized dysfunction of the humoral immune system. History of autoimmunity should alert the clinician to the possibility of NMO spectrum disorder in a patient presenting with isolated ON.
AB - Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder characterized by monophasic or recurrent attacks of optic neuritis (ON) and transverse myelitis. NMO spectrum disorders include patients who are seropositive for NMO-IgG antibody and have experienced at least 1 demyelinating attack. NMO has been associated with other autoimmune conditions. We describe a patient diagnosed with autoimmune hemolytic anemia and marginal zone lymphoma, who later developed NMO-IgG seropositive ON. The coexistence of multiple immunologic abnormalities in this patient points to a generalized dysfunction of the humoral immune system. History of autoimmunity should alert the clinician to the possibility of NMO spectrum disorder in a patient presenting with isolated ON.
KW - Autoimmune hemolytic anemia
KW - Lymphoma
KW - Neuromyelitis optica
KW - Optic neuritis
UR - http://www.scopus.com/inward/record.url?scp=84946145219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946145219&partnerID=8YFLogxK
U2 - 10.1097/NRL.0000000000000043
DO - 10.1097/NRL.0000000000000043
M3 - Article
C2 - 26280288
AN - SCOPUS:84946145219
SN - 1074-7931
VL - 20
SP - 33
EP - 34
JO - Neurologist
JF - Neurologist
IS - 2
ER -