Neuron specific enolase in human small cell carcinoma cultures

P. J. Marangos, A. F. Gazdar, D. N. Carney

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Continuous cell lines of human lung cancers were analyzed for neuron specific enolase (NSE). The levels of NSE in the small cell carcinoma cells were in every case much higher than those derived from other forms of lung cancer. Since NSE is strictly localized to neurons and neuroendocrine cells of the amine precursor uptake and decarboxylation (APUD) series, the data provided further evidence that small cell carcinoma is an APUD cell tumor and is distinct from other forms of lung cancer.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalCancer Letters
Volume15
Issue number1
DOIs
StatePublished - 1982

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Small Cell Carcinoma
Phosphopyruvate Hydratase
Lung Neoplasms
Cell Culture Techniques
APUD Cells
Neuroendocrine Cells
Decarboxylation
Amines
Neurons
Cell Line
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Neuron specific enolase in human small cell carcinoma cultures. / Marangos, P. J.; Gazdar, A. F.; Carney, D. N.

In: Cancer Letters, Vol. 15, No. 1, 1982, p. 67-71.

Research output: Contribution to journalArticle

Marangos, P. J. ; Gazdar, A. F. ; Carney, D. N. / Neuron specific enolase in human small cell carcinoma cultures. In: Cancer Letters. 1982 ; Vol. 15, No. 1. pp. 67-71.
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