Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

Ilya Bezprozvanny, Mark P. Mattson

Research output: Contribution to journalArticle

522 Citations (Scopus)

Abstract

Perturbed neuronal Ca2+ homeostasis is implicated in age-related cognitive impairment and Alzheimer's disease (AD). With advancing age, neurons encounter increased oxidative stress and impaired energy metabolism, which compromise the function of proteins that control membrane excitability and subcellular Ca2+ dynamics. Toxic forms of amyloid β-peptide (Aβ) can induce Ca2+ influx into neurons by inducing membrane-associated oxidative stress or by forming an oligomeric pore in the membrane, thereby rendering neurons vulnerable to excitotoxicity and apoptosis. AD-causing mutations in the β-amyloid precursor protein and presenilins can compromise these normal proteins in the plasma membrane and endoplasmic reticulum, respectively. Emerging knowledge of the actions of Ca2+ upstream and downstream of Aβ provides opportunities to develop novel preventative and therapeutic interventions for AD.

Original languageEnglish (US)
Pages (from-to)454-463
Number of pages10
JournalTrends in Neurosciences
Volume31
Issue number9
DOIs
StatePublished - Sep 2008

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Alzheimer Disease
Calcium
Neurons
Oxidative Stress
Presenilins
Membranes
Amyloid beta-Protein Precursor
Poisons
Amyloid
Endoplasmic Reticulum
Energy Metabolism
Membrane Proteins
Homeostasis
Cell Membrane
Apoptosis
Mutation
Proteins
Therapeutics
peptide A
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. / Bezprozvanny, Ilya; Mattson, Mark P.

In: Trends in Neurosciences, Vol. 31, No. 9, 09.2008, p. 454-463.

Research output: Contribution to journalArticle

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