Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

Hiroyuki Nagashima; Tanel Mahlakõiv; Han Yu Shih; Fred P. Davis; Francoise Meylan; Yuefeng Huang; Oliver J. Harrison; Chen Yao; Yohei Mikami; Joseph F. Urban; Kathleen M. Caron; Yasmine Belkaid; Yuka Kanno; David Artis; John J. O'Shea

doi:10.1016/j.immuni.2019.06.009

Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

Hiroyuki Nagashima, Tanel Mahlakõiv, Han Yu Shih, Fred P. Davis, Francoise Meylan, Yuefeng Huang, Oliver J. Harrison, Chen Yao, Yohei Mikami, Joseph F. Urban, Kathleen M. Caron, Yasmine Belkaid, Yuka Kanno, David Artis, John J. O'Shea

Research output: Contribution to journal › Article › peer-review

185 Scopus citations

Abstract

Neuronal and immune systems coordinately orchestrate responses at mucosal barriers. Nagashima et al. applied scRNA-seq technology to track type 2 immune responses in worm infection, identifying neuropeptide CGRP as a factor that modulates inflammation. The study suggests that CGRP may be a useful target in type 2 inflammation.

Original language	English (US)
Pages (from-to)	682-695.e6
Journal	Immunity
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2019.06.009
State	Published - Oct 15 2019
Externally published	Yes

Keywords

CGRP
IL-33
NMU
Nippostrongylus brasiliensis
cytokines
host defense
immunoregulation
innate lymphoid cells
neuropeptides
single-cell RNA-seq

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2019.06.009

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Nagashima, H., Mahlakõiv, T., Shih, H. Y., Davis, F. P., Meylan, F., Huang, Y., Harrison, O. J., Yao, C., Mikami, Y., Urban, J. F., Caron, K. M., Belkaid, Y., Kanno, Y., Artis, D., & O'Shea, J. J. (2019). Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Immunity, 51(4), 682-695.e6. https://doi.org/10.1016/j.immuni.2019.06.009

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title = "Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation",

abstract = "Neuronal and immune systems coordinately orchestrate responses at mucosal barriers. Nagashima et al. applied scRNA-seq technology to track type 2 immune responses in worm infection, identifying neuropeptide CGRP as a factor that modulates inflammation. The study suggests that CGRP may be a useful target in type 2 inflammation.",

keywords = "CGRP, IL-33, NMU, Nippostrongylus brasiliensis, cytokines, host defense, immunoregulation, innate lymphoid cells, neuropeptides, single-cell RNA-seq",

author = "Hiroyuki Nagashima and Tanel Mahlak{\~o}iv and Shih, {Han Yu} and Davis, {Fred P.} and Francoise Meylan and Yuefeng Huang and Harrison, {Oliver J.} and Chen Yao and Yohei Mikami and Urban, {Joseph F.} and Caron, {Kathleen M.} and Yasmine Belkaid and Yuka Kanno and David Artis and O'Shea, {John J.}",

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doi = "10.1016/j.immuni.2019.06.009",

language = "English (US)",

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T1 - Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

AU - Nagashima, Hiroyuki

AU - Mahlakõiv, Tanel

AU - Shih, Han Yu

AU - Davis, Fred P.

AU - Meylan, Francoise

AU - Huang, Yuefeng

AU - Harrison, Oliver J.

AU - Yao, Chen

AU - Mikami, Yohei

AU - Urban, Joseph F.

AU - Caron, Kathleen M.

AU - Belkaid, Yasmine

AU - Kanno, Yuka

AU - Artis, David

AU - O'Shea, John J.

PY - 2019/10/15

Y1 - 2019/10/15

N2 - Neuronal and immune systems coordinately orchestrate responses at mucosal barriers. Nagashima et al. applied scRNA-seq technology to track type 2 immune responses in worm infection, identifying neuropeptide CGRP as a factor that modulates inflammation. The study suggests that CGRP may be a useful target in type 2 inflammation.

AB - Neuronal and immune systems coordinately orchestrate responses at mucosal barriers. Nagashima et al. applied scRNA-seq technology to track type 2 immune responses in worm infection, identifying neuropeptide CGRP as a factor that modulates inflammation. The study suggests that CGRP may be a useful target in type 2 inflammation.

KW - CGRP

KW - IL-33

KW - NMU

KW - Nippostrongylus brasiliensis

KW - cytokines

KW - host defense

KW - immunoregulation

KW - innate lymphoid cells

KW - neuropeptides

KW - single-cell RNA-seq

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SN - 1074-7613

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JO - Immunity

JF - Immunity

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ER -

Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation

Abstract

Keywords

ASJC Scopus subject areas

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