Neuroprotection in acute brain injury: An up-to-date review

Nino Stocchetti, Fabio S. Taccone, Giuseppe Citerio, Paul E. Pepe, Peter D. Roux, Mauro Oddo, Kees H. Polderman, Robert D. Stevens, William Barsan, Andrew I R Maas, Geert Meyfroidt, Michael J. Bell, Robert Silbergleit, Paul M. Vespa, Alan I. Faden, Raimund Helbok, Samuel Tisherman, Elisa R. Zanier, Terence Valenzuela, Julia WendonDavid K. Menon, Jean Louis Vincent

Research output: Contribution to journalReview article

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Abstract

Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

Original languageEnglish (US)
Article number186
JournalCritical Care
Volume19
Issue number1
DOIs
StatePublished - Apr 21 2015

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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    Stocchetti, N., Taccone, F. S., Citerio, G., Pepe, P. E., Roux, P. D., Oddo, M., Polderman, K. H., Stevens, R. D., Barsan, W., Maas, A. I. R., Meyfroidt, G., Bell, M. J., Silbergleit, R., Vespa, P. M., Faden, A. I., Helbok, R., Tisherman, S., Zanier, E. R., Valenzuela, T., ... Vincent, J. L. (2015). Neuroprotection in acute brain injury: An up-to-date review. Critical Care, 19(1), [186]. https://doi.org/10.1186/s13054-015-0887-8