Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease

A. V. Bol’shakova, N. A. Kraskovskaya, A. N. Gainullina, E. O. Kukanova, O. L. Vlasova, I. B. Bezprozvanny

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Huntington’s disease is a hereditary neurodegenerative disease that primarily affects striatal neurons. Recent studies demonstrated abnormalities in calcium regulation in striatal neurons in Huntington’s disease, which leads to elimination of synaptic connections between cortical and striatal neurons. In the present study, we focused on the neuroprotective properties of σ1-receptor, because one of its main functions is associated with modulation of calcium homeostasis in cells. The application of selective σ1-receptor agonists to the corticostriatal cell culture restores synaptic connections between the cortical and striatal neurons. Based on the obtained data, we assume that σ1-receptor is a promising target for the development of drugs for the therapy of Huntington’s disease.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalBulletin of Experimental Biology and Medicine
Volume164
Issue number2
DOIs
StatePublished - Dec 1 2017

Keywords

  • cortico-striatal cell cultures
  • dendritic spines
  • Huntington’s disease
  • medium spiny neurons
  • σ1-receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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