Neuroprotective fractalkine in fetal alcohol syndrome

Robin Roberson, Thea Kuddo, Ines Benassou, Daniel Abebe, Catherine Spong

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective: Neuroprotective peptides (SALLRSIPA [SAL] and NAPVSIPQ [NAP]) can prevent some alcohol-induced damage in fetal alcohol syndrome (FAS). Fractalkine, a chemokine constitutively expressed in the central nervous system reduces neuronal death from activated microglia. Using a model of FAS, we evaluated whether fractalkine is altered and whether NAP + SAL work through fractalkine. Study Design: With an FAS model, C57BL6/J-mice were treated on gestational day 8 with alcohol (0.03 mL/g), placebo, or alcohol + peptides. Embryos were harvested after 6 hours and 10 days later. Fractalkine was measured in the protein lysate. Statistical analysis included the Kruskal-Wallis test. Results: Fractalkine was significantly elevated at 6 hours (median, 341pg/mL; range, 263424 pg/mL) vs controls (median, 228 pg/mL; range, 146332 pg/mL; P < .001). NAP + SAL prevented the alcohol-induced increase (median, 137 pg/mL; range, 97255 pg/mL; P < .001). Ten days later, fractalkine levels were similar in all groups (P = .7). Conclusion: Prenatal alcohol exposure acutely elevates fractalkine, perhaps in an effort to counter the alcohol toxicity. Pretreatment with NAP + SAL prevents the acute increase in fractalkine.

Original languageEnglish (US)
Pages (from-to)400.e1-400.e3
JournalAmerican journal of obstetrics and gynecology
Volume204
Issue number5
DOIs
StatePublished - May 2011
Externally publishedYes

Keywords

  • NAPVSIPQ
  • SALLRSIPA
  • fetal alcohol syndrome
  • fractalkine

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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