Serial neuropsychologic studies were performed in 18 children following surgery and irradiation for brain tumors. Initial evaluations (1) 3-70 months post therapy (median 22 months) revealed subnormal full scale IQ (FSIQ < 90) in nine. Time elapsed since treatment did not significantly correlate with IQ or memory scores. Second evaluations (#2) 10-23 months after #1 showed FSIQ stability in 12 (67%) and improvement (FSIQ ≥ 10 points higher) in three. Deterioration (FSIQ ≥ 10 points lower) was noted in three, in each case associated with clinically significant neurologic events. Serial memory scores improved in two, remained stable in 10, and declined in six. Third evaluations (#3), 6-23 months after #2, documented FSIQ stability in 8/9 studied and significant, late improvement in one. The effect of age is suggested primarily in memory-oriented functions. Selective attending is abnormal at #1 in 6/9 < 6 years old at diagnosis, and 1/9 ≥ 6 years. Interval decline in memory scores between #1 and #2 occurred in 5/9 < 6 years old at diagnosis, and 1/9 ≥ 6 years. The findings support earlier observations of relative declines in intellectual function in this population. Identification of intellectual delays requiring special educational assistance permits learning intervention early in the child's course. Substantial interval improvement apparent in 4/18 children indicates some degree of repair or adaptation with time, likely affected by directed educational programs.
|Original language||English (US)|
|Number of pages||6|
|Journal||American Journal of Clinical Oncology: Cancer Clinical Trials|
|State||Published - Jan 1 1983|
ASJC Scopus subject areas
- Cancer Research