Neuropsychological and eye movement abnormalities in first-episode and chronic schizophrenia

John A. Sweeney, Gretchen L. Haas, Shuhua Li

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

It is well known that neurobehavioral deficits are associated with schizophrenia. Little is known, however, about whether these disturbances become more severe over the course of the illness. In the present study, 101 patients with schizophrenia, of whom 45 were firstepisode cases, performed pursuit eye tracking tasks. A subset of 60 of these patients, including 27 firstepisode cases, were administered a battery of neuropsychological tests, Patients with a history of prior psychotic episodes demonstrated more severe pursuit eye movement dysfunction than first-episode patients and more severe disturbances on neuropsychological tests sensitive to prefrontal and left temporal cortical dysfunction. Longitudinal studies of patients ascertained close to the point of illness onset are needed to determine whether these findings reflect a progressive deterioration in neurobehavioral functioning over the course of schizophrenia.

Original languageEnglish (US)
Pages (from-to)283-293
Number of pages11
JournalSchizophrenia bulletin
Volume18
Issue number2
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Psychiatry and Mental health

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