Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia

Elliott P. Vichinsky, Lynne D. Neumayr, Jeffrey I. Gold, Michael W. Weiner, Randall R. Rule, Diana Truran, Jeffrey Kasten, Barry Eggleston, Karen Kesler, Lillian McMahon, Eugene P. Orringer, Thomas Harrington, Karen Kalinyak, Laura M. De Castro, Abdullah Kutlar, Cynthia J. Rutherford, Cage Johnson, Joel David Bessman, Lanetta B. Jordan, F. Daniel Armstrong

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Context: Sickle cell anemia (SCA) is a chronic illness causing progressive deterioration in quality of life. Brain dysfunction may be the most important and least studied problem affecting individuals with this disease. Objective: To measure neurocognitive dysfunction in neurologically asymptomatic adults with SCA vs healthy control individuals. Design, Setting, and Participants: Cross-sectional study comparing neuropsychological function and neuroimaging findings in neurologically asymptomatic adults with SCA and controls from 12 SCA centers, conducted between December 2004 and May 2008. Participants were patients with SCA (hemoglobin [Hb] SS and hemoglobin level ≤10 mg/dL) aged 19 to 55 years and of African descent (n=149) or community controls (Hb AA and normal hemoglobin level) (n=47). Participants were stratified on age, sex, and education. Main Outcome Measures: The primary outcome measure was nonverbal function assessed by the Wechsler Adult Intelligence Scale, third edition (WAIS-III) Performance IQ Index. Secondary exploratory outcomes included performance on neurocognitive tests of executive function, memory, attention, and language and magnetic resonance imaging measurement of total intracranial and hippocampal volume, cortical gray and white matter, and lacunae. Results: The mean WAIS-III Performance IQ score of patients with SCA was significantly lower than that of controls (adjusted mean, 86.69 for patients with SCA vs 95.19 for controls [mean difference, -5.50; 95% confidence interval {CI}, -9.55 to -1.44]; P=.008), with 33% performing more than 1 SD (<85) below the population mean. Among secondary measures, differences were observed in adjusted mean values for global cognitive function (full-scale IQ) (90.47 for patients with SCA vs 95.66 for controls [mean difference, -5.19; 95% CI, -9.24 to -1.13]; P=.01), working memory (90.75 vs 95.25 [mean difference, -4.50; 95% CI, -8.55 to -0.45]; P=.03), processing speed (86.50 vs 97.95 [mean difference, -11.46; 95% CI, -15.51 to -7.40]; P<.001), and measures of executive function. Anemia was associated with poorer neurocognitive function in older patients. No differences in total gray matter or hippocampal volume were observed. Lacunae were more frequent in patients with SCA but not independently related to neurocognitive function. Conclusion: Compared with healthy controls, adults with SCA had poorer cognitive performance, which was associated with anemia and age.

Original languageEnglish (US)
Pages (from-to)1823-1831
Number of pages9
JournalJAMA - Journal of the American Medical Association
Volume303
Issue number18
DOIs
StatePublished - May 12 2010

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Sickle Cell Anemia
Neuroimaging
Confidence Intervals
Executive Function
Intelligence
Anemia
Hemoglobins
Outcome Assessment (Health Care)
Sickle Hemoglobin
Sex Education
Short-Term Memory
Cognition
Chronic Disease
Language
Cross-Sectional Studies
Quality of Life
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vichinsky, E. P., Neumayr, L. D., Gold, J. I., Weiner, M. W., Rule, R. R., Truran, D., ... Armstrong, F. D. (2010). Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA - Journal of the American Medical Association, 303(18), 1823-1831. https://doi.org/10.1001/jama.2010.562

Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. / Vichinsky, Elliott P.; Neumayr, Lynne D.; Gold, Jeffrey I.; Weiner, Michael W.; Rule, Randall R.; Truran, Diana; Kasten, Jeffrey; Eggleston, Barry; Kesler, Karen; McMahon, Lillian; Orringer, Eugene P.; Harrington, Thomas; Kalinyak, Karen; De Castro, Laura M.; Kutlar, Abdullah; Rutherford, Cynthia J.; Johnson, Cage; Bessman, Joel David; Jordan, Lanetta B.; Armstrong, F. Daniel.

In: JAMA - Journal of the American Medical Association, Vol. 303, No. 18, 12.05.2010, p. 1823-1831.

Research output: Contribution to journalArticle

Vichinsky, EP, Neumayr, LD, Gold, JI, Weiner, MW, Rule, RR, Truran, D, Kasten, J, Eggleston, B, Kesler, K, McMahon, L, Orringer, EP, Harrington, T, Kalinyak, K, De Castro, LM, Kutlar, A, Rutherford, CJ, Johnson, C, Bessman, JD, Jordan, LB & Armstrong, FD 2010, 'Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia', JAMA - Journal of the American Medical Association, vol. 303, no. 18, pp. 1823-1831. https://doi.org/10.1001/jama.2010.562
Vichinsky, Elliott P. ; Neumayr, Lynne D. ; Gold, Jeffrey I. ; Weiner, Michael W. ; Rule, Randall R. ; Truran, Diana ; Kasten, Jeffrey ; Eggleston, Barry ; Kesler, Karen ; McMahon, Lillian ; Orringer, Eugene P. ; Harrington, Thomas ; Kalinyak, Karen ; De Castro, Laura M. ; Kutlar, Abdullah ; Rutherford, Cynthia J. ; Johnson, Cage ; Bessman, Joel David ; Jordan, Lanetta B. ; Armstrong, F. Daniel. / Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. In: JAMA - Journal of the American Medical Association. 2010 ; Vol. 303, No. 18. pp. 1823-1831.
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abstract = "Context: Sickle cell anemia (SCA) is a chronic illness causing progressive deterioration in quality of life. Brain dysfunction may be the most important and least studied problem affecting individuals with this disease. Objective: To measure neurocognitive dysfunction in neurologically asymptomatic adults with SCA vs healthy control individuals. Design, Setting, and Participants: Cross-sectional study comparing neuropsychological function and neuroimaging findings in neurologically asymptomatic adults with SCA and controls from 12 SCA centers, conducted between December 2004 and May 2008. Participants were patients with SCA (hemoglobin [Hb] SS and hemoglobin level ≤10 mg/dL) aged 19 to 55 years and of African descent (n=149) or community controls (Hb AA and normal hemoglobin level) (n=47). Participants were stratified on age, sex, and education. Main Outcome Measures: The primary outcome measure was nonverbal function assessed by the Wechsler Adult Intelligence Scale, third edition (WAIS-III) Performance IQ Index. Secondary exploratory outcomes included performance on neurocognitive tests of executive function, memory, attention, and language and magnetic resonance imaging measurement of total intracranial and hippocampal volume, cortical gray and white matter, and lacunae. Results: The mean WAIS-III Performance IQ score of patients with SCA was significantly lower than that of controls (adjusted mean, 86.69 for patients with SCA vs 95.19 for controls [mean difference, -5.50; 95{\%} confidence interval {CI}, -9.55 to -1.44]; P=.008), with 33{\%} performing more than 1 SD (<85) below the population mean. Among secondary measures, differences were observed in adjusted mean values for global cognitive function (full-scale IQ) (90.47 for patients with SCA vs 95.66 for controls [mean difference, -5.19; 95{\%} CI, -9.24 to -1.13]; P=.01), working memory (90.75 vs 95.25 [mean difference, -4.50; 95{\%} CI, -8.55 to -0.45]; P=.03), processing speed (86.50 vs 97.95 [mean difference, -11.46; 95{\%} CI, -15.51 to -7.40]; P<.001), and measures of executive function. Anemia was associated with poorer neurocognitive function in older patients. No differences in total gray matter or hippocampal volume were observed. Lacunae were more frequent in patients with SCA but not independently related to neurocognitive function. Conclusion: Compared with healthy controls, adults with SCA had poorer cognitive performance, which was associated with anemia and age.",
author = "Vichinsky, {Elliott P.} and Neumayr, {Lynne D.} and Gold, {Jeffrey I.} and Weiner, {Michael W.} and Rule, {Randall R.} and Diana Truran and Jeffrey Kasten and Barry Eggleston and Karen Kesler and Lillian McMahon and Orringer, {Eugene P.} and Thomas Harrington and Karen Kalinyak and {De Castro}, {Laura M.} and Abdullah Kutlar and Rutherford, {Cynthia J.} and Cage Johnson and Bessman, {Joel David} and Jordan, {Lanetta B.} and Armstrong, {F. Daniel}",
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TY - JOUR

T1 - Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia

AU - Vichinsky, Elliott P.

AU - Neumayr, Lynne D.

AU - Gold, Jeffrey I.

AU - Weiner, Michael W.

AU - Rule, Randall R.

AU - Truran, Diana

AU - Kasten, Jeffrey

AU - Eggleston, Barry

AU - Kesler, Karen

AU - McMahon, Lillian

AU - Orringer, Eugene P.

AU - Harrington, Thomas

AU - Kalinyak, Karen

AU - De Castro, Laura M.

AU - Kutlar, Abdullah

AU - Rutherford, Cynthia J.

AU - Johnson, Cage

AU - Bessman, Joel David

AU - Jordan, Lanetta B.

AU - Armstrong, F. Daniel

PY - 2010/5/12

Y1 - 2010/5/12

N2 - Context: Sickle cell anemia (SCA) is a chronic illness causing progressive deterioration in quality of life. Brain dysfunction may be the most important and least studied problem affecting individuals with this disease. Objective: To measure neurocognitive dysfunction in neurologically asymptomatic adults with SCA vs healthy control individuals. Design, Setting, and Participants: Cross-sectional study comparing neuropsychological function and neuroimaging findings in neurologically asymptomatic adults with SCA and controls from 12 SCA centers, conducted between December 2004 and May 2008. Participants were patients with SCA (hemoglobin [Hb] SS and hemoglobin level ≤10 mg/dL) aged 19 to 55 years and of African descent (n=149) or community controls (Hb AA and normal hemoglobin level) (n=47). Participants were stratified on age, sex, and education. Main Outcome Measures: The primary outcome measure was nonverbal function assessed by the Wechsler Adult Intelligence Scale, third edition (WAIS-III) Performance IQ Index. Secondary exploratory outcomes included performance on neurocognitive tests of executive function, memory, attention, and language and magnetic resonance imaging measurement of total intracranial and hippocampal volume, cortical gray and white matter, and lacunae. Results: The mean WAIS-III Performance IQ score of patients with SCA was significantly lower than that of controls (adjusted mean, 86.69 for patients with SCA vs 95.19 for controls [mean difference, -5.50; 95% confidence interval {CI}, -9.55 to -1.44]; P=.008), with 33% performing more than 1 SD (<85) below the population mean. Among secondary measures, differences were observed in adjusted mean values for global cognitive function (full-scale IQ) (90.47 for patients with SCA vs 95.66 for controls [mean difference, -5.19; 95% CI, -9.24 to -1.13]; P=.01), working memory (90.75 vs 95.25 [mean difference, -4.50; 95% CI, -8.55 to -0.45]; P=.03), processing speed (86.50 vs 97.95 [mean difference, -11.46; 95% CI, -15.51 to -7.40]; P<.001), and measures of executive function. Anemia was associated with poorer neurocognitive function in older patients. No differences in total gray matter or hippocampal volume were observed. Lacunae were more frequent in patients with SCA but not independently related to neurocognitive function. Conclusion: Compared with healthy controls, adults with SCA had poorer cognitive performance, which was associated with anemia and age.

AB - Context: Sickle cell anemia (SCA) is a chronic illness causing progressive deterioration in quality of life. Brain dysfunction may be the most important and least studied problem affecting individuals with this disease. Objective: To measure neurocognitive dysfunction in neurologically asymptomatic adults with SCA vs healthy control individuals. Design, Setting, and Participants: Cross-sectional study comparing neuropsychological function and neuroimaging findings in neurologically asymptomatic adults with SCA and controls from 12 SCA centers, conducted between December 2004 and May 2008. Participants were patients with SCA (hemoglobin [Hb] SS and hemoglobin level ≤10 mg/dL) aged 19 to 55 years and of African descent (n=149) or community controls (Hb AA and normal hemoglobin level) (n=47). Participants were stratified on age, sex, and education. Main Outcome Measures: The primary outcome measure was nonverbal function assessed by the Wechsler Adult Intelligence Scale, third edition (WAIS-III) Performance IQ Index. Secondary exploratory outcomes included performance on neurocognitive tests of executive function, memory, attention, and language and magnetic resonance imaging measurement of total intracranial and hippocampal volume, cortical gray and white matter, and lacunae. Results: The mean WAIS-III Performance IQ score of patients with SCA was significantly lower than that of controls (adjusted mean, 86.69 for patients with SCA vs 95.19 for controls [mean difference, -5.50; 95% confidence interval {CI}, -9.55 to -1.44]; P=.008), with 33% performing more than 1 SD (<85) below the population mean. Among secondary measures, differences were observed in adjusted mean values for global cognitive function (full-scale IQ) (90.47 for patients with SCA vs 95.66 for controls [mean difference, -5.19; 95% CI, -9.24 to -1.13]; P=.01), working memory (90.75 vs 95.25 [mean difference, -4.50; 95% CI, -8.55 to -0.45]; P=.03), processing speed (86.50 vs 97.95 [mean difference, -11.46; 95% CI, -15.51 to -7.40]; P<.001), and measures of executive function. Anemia was associated with poorer neurocognitive function in older patients. No differences in total gray matter or hippocampal volume were observed. Lacunae were more frequent in patients with SCA but not independently related to neurocognitive function. Conclusion: Compared with healthy controls, adults with SCA had poorer cognitive performance, which was associated with anemia and age.

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