Neuropsychological functioning in MRI-derived subgroups of schizophrenia

I. J. Osuji, A. McGarrahan, P. Mihalakos, D. Garver, S. Kingsbury, C. M. Cullum

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


This study examined neuropsychological functioning in two subgroups of patients with familial schizophrenia. Those who showed evidence of progressive ventricular enlargement observed across serial MRI scans (n = 6) were compared with subjects whose ventricular volume remained static (n = 10) over an average of 28 months. No differences were found in terms of age, education, ethnicity, level of psychotic symptomatology, DSM-IV subtype, age of onset, or duration of illness. Neurocognitively, the static ventricle group was impaired across more cognitive domains and had a larger percentage of subjects falling into the impaired range on a majority of measures, with the greatest differences on measures of attention (p < 0.02) and nonverbal memory (p < 0.07). These results suggest that clinically meaningful differences between these two MRI-derived subgroups of patients with schizophrenia may exist, and further underscore the heterogeneity of the illness.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalSchizophrenia Research
Issue number1-3
StatePublished - May 1 2007


  • Cognition
  • MRI
  • Neuropsychology
  • Schizophrenia
  • Ventricle volume

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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