Abstract
This study examined neuropsychological functioning in two subgroups of patients with familial schizophrenia. Those who showed evidence of progressive ventricular enlargement observed across serial MRI scans (n = 6) were compared with subjects whose ventricular volume remained static (n = 10) over an average of 28 months. No differences were found in terms of age, education, ethnicity, level of psychotic symptomatology, DSM-IV subtype, age of onset, or duration of illness. Neurocognitively, the static ventricle group was impaired across more cognitive domains and had a larger percentage of subjects falling into the impaired range on a majority of measures, with the greatest differences on measures of attention (p < 0.02) and nonverbal memory (p < 0.07). These results suggest that clinically meaningful differences between these two MRI-derived subgroups of patients with schizophrenia may exist, and further underscore the heterogeneity of the illness.
Original language | English (US) |
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Pages (from-to) | 189-196 |
Number of pages | 8 |
Journal | Schizophrenia Research |
Volume | 92 |
Issue number | 1-3 |
DOIs | |
State | Published - May 2007 |
Keywords
- Cognition
- MRI
- Neuropsychology
- Schizophrenia
- Ventricle volume
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry