Neuropsychological outcomes of pediatric demyelinating diseases: a review

Alexander Tan, Cole Hague, Benjamin M. Greenberg, Lana Harder

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Immune-mediated central nervous system (CNS) demyelinating diseases impact various areas of the brain, optic nerves, and/or spinal cord and can result in a wide range of neurologic symptoms including adverse cognitive outcomes. Neuropsychological outcomes in adult multiple sclerosis (MS) are well documented, while literature on such outcomes in pediatric cohorts is more limited. Furthermore, literature on neuropsychological outcomes in pediatric acute disseminated encephalomyelitis (ADEM), neuromyelitis optica (NMO), and transverse myelitis (TM) is even more limited. This paper is the first to review what is known about neuropsychological outcomes associated with immune-mediated CNS demyelinating diseases, with a focus on pediatric MS, ADEM, NMO, and TM. Additionally, this review illuminates the need to clarify differences in neuropsychological sequelae between conditions, characterize longitudinal cognitive outcomes, and investigate neuropsychological outcomes in relation to clinical variables (e.g., age of onset, disease duration, number of relapses) and psychosocial variables (e.g., fatigue, emotional problems, behavioral functioning) to better understand neuropsychological outcomes associated with these conditions.

Original languageEnglish (US)
Pages (from-to)1-23
Number of pages23
JournalChild Neuropsychology
StateAccepted/In press - Jun 23 2017


  • ADEM
  • Demyelinating
  • multiple sclerosis
  • neuropsychology
  • pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Medicine(all)
  • Developmental and Educational Psychology


Dive into the research topics of 'Neuropsychological outcomes of pediatric demyelinating diseases: a review'. Together they form a unique fingerprint.

Cite this