Neuroscience: Synaptic patterning by morphogen signaling

W. Ryan Williamson, P. Robin Hiesinger

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Gradients of secreted small morphogenic molecules control cell proliferation and patterning throughout animal development. Recent years have seen the discovery of surprising roles for morphogens in later developmental processes, including axon pathfinding and synaptogenesis. The latest addition is a role for the TGF-β superfamily morphogen Activin in synaptic patterning of the Drosophila visual system. In contrast to classical instructive and long-range morphogen gradients, Activin acts as a permissive and local motility restriction signal around several hundred individual photoreceptor axon terminals. Activin must therefore act in concert with other instructively attracting and repelling signals as part of a larger genetic program for brain wiring.

Original languageEnglish (US)
Pages (from-to)pe20
JournalScience signaling
Volume1
Issue number18
DOIs
StatePublished - May 6 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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