Neuroscience: Synaptic patterning by morphogen signaling

W. Ryan Williamson, P. Robin Hiesinger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Gradients of secreted small morphogenic molecules control cell proliferation and patterning throughout animal development. Recent years have seen the discovery of surprising roles for morphogens in later developmental processes, including axon pathfinding and synaptogenesis. The latest addition is a role for the TGF-β superfamily morphogen Activin in synaptic patterning of the Drosophila visual system. In contrast to classical instructive and long-range morphogen gradients, Activin acts as a permissive and local motility restriction signal around several hundred individual photoreceptor axon terminals. Activin must therefore act in concert with other instructively attracting and repelling signals as part of a larger genetic program for brain wiring.

Original languageEnglish (US)
JournalScience Signaling
Volume1
Issue number18
DOIs
StatePublished - May 6 2008

Fingerprint

Activins
Neurosciences
Presynaptic Terminals
Cell proliferation
Electric wiring
Drosophila
Brain
Animals
Cell Proliferation
Molecules
Axons

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Neuroscience : Synaptic patterning by morphogen signaling. / Williamson, W. Ryan; Hiesinger, P. Robin.

In: Science Signaling, Vol. 1, No. 18, 06.05.2008.

Research output: Contribution to journalArticle

Williamson, W. Ryan ; Hiesinger, P. Robin. / Neuroscience : Synaptic patterning by morphogen signaling. In: Science Signaling. 2008 ; Vol. 1, No. 18.
@article{54815088816b4f03ae7a8ee79c60c2d1,
title = "Neuroscience: Synaptic patterning by morphogen signaling",
abstract = "Gradients of secreted small morphogenic molecules control cell proliferation and patterning throughout animal development. Recent years have seen the discovery of surprising roles for morphogens in later developmental processes, including axon pathfinding and synaptogenesis. The latest addition is a role for the TGF-β superfamily morphogen Activin in synaptic patterning of the Drosophila visual system. In contrast to classical instructive and long-range morphogen gradients, Activin acts as a permissive and local motility restriction signal around several hundred individual photoreceptor axon terminals. Activin must therefore act in concert with other instructively attracting and repelling signals as part of a larger genetic program for brain wiring.",
author = "Williamson, {W. Ryan} and Hiesinger, {P. Robin}",
year = "2008",
month = "5",
day = "6",
doi = "10.1126/stke.118pe20",
language = "English (US)",
volume = "1",
journal = "Science Signaling",
issn = "1937-9145",
publisher = "American Association for the Advancement of Science",
number = "18",

}

TY - JOUR

T1 - Neuroscience

T2 - Synaptic patterning by morphogen signaling

AU - Williamson, W. Ryan

AU - Hiesinger, P. Robin

PY - 2008/5/6

Y1 - 2008/5/6

N2 - Gradients of secreted small morphogenic molecules control cell proliferation and patterning throughout animal development. Recent years have seen the discovery of surprising roles for morphogens in later developmental processes, including axon pathfinding and synaptogenesis. The latest addition is a role for the TGF-β superfamily morphogen Activin in synaptic patterning of the Drosophila visual system. In contrast to classical instructive and long-range morphogen gradients, Activin acts as a permissive and local motility restriction signal around several hundred individual photoreceptor axon terminals. Activin must therefore act in concert with other instructively attracting and repelling signals as part of a larger genetic program for brain wiring.

AB - Gradients of secreted small morphogenic molecules control cell proliferation and patterning throughout animal development. Recent years have seen the discovery of surprising roles for morphogens in later developmental processes, including axon pathfinding and synaptogenesis. The latest addition is a role for the TGF-β superfamily morphogen Activin in synaptic patterning of the Drosophila visual system. In contrast to classical instructive and long-range morphogen gradients, Activin acts as a permissive and local motility restriction signal around several hundred individual photoreceptor axon terminals. Activin must therefore act in concert with other instructively attracting and repelling signals as part of a larger genetic program for brain wiring.

UR - http://www.scopus.com/inward/record.url?scp=48149102007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48149102007&partnerID=8YFLogxK

U2 - 10.1126/stke.118pe20

DO - 10.1126/stke.118pe20

M3 - Article

C2 - 18460681

AN - SCOPUS:48149102007

VL - 1

JO - Science Signaling

JF - Science Signaling

SN - 1937-9145

IS - 18

ER -