Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea

Aviv D. Goldbart, Edward Mager, Maria C. Veling, Julie L. Goldman, Leila Kheirandish-Gozal, Laura D. Serpero, Giovanni Piedimonte, David Gozal

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Enlarged adenotonsillar tissue (AT) is a major determinant of obstructive sleep apnea (OSA) severity in children; however, mechanisms of AT proliferation are poorly understood. We hypothesized that early exposure to respiratory syncytial virus (RSV) may modify AT proliferation through up-regulation of nerve growth factor (NGF)-neurokinin 1 (NK1) receptor dependent pathways. AT harvested from 34 children with OSA and 25 children with recurrent tonsillitis (RI) were examined for mRNA expression of multiple growth factors and their receptors. In addition, NK1 receptor expression and location, and substance P tissue concentrations were compared in AT from OSA and RI children. NGF mRNA and its high-affinity tyrosine kinase receptor (trkA) expression were selectively increased in OSA (p < 0.001). NK1 receptor mRNA and protein expression were also enhanced in OSA (p < 0.01), and substance P concentrations in OSA patients were higher than in RI (p < 0.0001). AT from OSA children exhibit distinct differences in the expression of NGF and trkA receptors, NK1 receptors, and substance P. The homology between these changes and those observed in the lower airways following RSV infection suggests that RSV may have induced neuro-immunomodulatory changes within AT, predisposing them to increased proliferation, and ultimately contribute to emergence of OSA.

Original languageEnglish (US)
Pages (from-to)489-494
Number of pages6
JournalPediatric Research
Volume62
Issue number4
DOIs
StatePublished - Oct 2007

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Nerve Growth Factors
Obstructive Sleep Apnea
Hypertrophy
Neurokinin-1 Receptors
Nerve Growth Factor
Substance P
Respiratory Syncytial Viruses
Receptor Protein-Tyrosine Kinases
Messenger RNA
Respiratory Syncytial Virus Infections
Tonsillitis
Growth Factor Receptors
Up-Regulation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Goldbart, A. D., Mager, E., Veling, M. C., Goldman, J. L., Kheirandish-Gozal, L., Serpero, L. D., ... Gozal, D. (2007). Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. Pediatric Research, 62(4), 489-494. https://doi.org/10.1203/PDR.0b013e31814257ed

Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. / Goldbart, Aviv D.; Mager, Edward; Veling, Maria C.; Goldman, Julie L.; Kheirandish-Gozal, Leila; Serpero, Laura D.; Piedimonte, Giovanni; Gozal, David.

In: Pediatric Research, Vol. 62, No. 4, 10.2007, p. 489-494.

Research output: Contribution to journalArticle

Goldbart, AD, Mager, E, Veling, MC, Goldman, JL, Kheirandish-Gozal, L, Serpero, LD, Piedimonte, G & Gozal, D 2007, 'Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea', Pediatric Research, vol. 62, no. 4, pp. 489-494. https://doi.org/10.1203/PDR.0b013e31814257ed
Goldbart, Aviv D. ; Mager, Edward ; Veling, Maria C. ; Goldman, Julie L. ; Kheirandish-Gozal, Leila ; Serpero, Laura D. ; Piedimonte, Giovanni ; Gozal, David. / Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea. In: Pediatric Research. 2007 ; Vol. 62, No. 4. pp. 489-494.
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