Neurovascular coupling during spreading depolarizations

Ulrike Hoffmann, Cenk Ayata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

16 Scopus citations

Abstract

Injury depolarizations akin to spreading depression of Leão are important in the progression of tissue damage in ischemic stroke, intracranial hemorrhage, and trauma. Much of the research on injury depolarizations has been focused on their origins, electrophysiological mechanisms, and metabolic impact. Recent studies showed that injury depolarizations cause vasoconstriction and diminish perfusion, which radically differs from the predominantly hyperemic response to spreading depression in otherwise-normal brain tissue. This adverse hemodynamic effect exacerbates metabolic supply-demand mismatch and worsens the tissue outcome. Although the mechanisms transforming the hemodynamic response from vasodilation into vasoconstriction are unclear, recent data suggest a role for elevated extracellular K+ and reduced intravascular perfusion pressure, among other factors. Clues from physiological and pharmacological studies in normal or injured brain in different species suggest that the intense pandepolarization evokes multiple opposing vasomotor mechanisms with variable magnitudes and timing, providing a conceptual framework to dissect the complex neurovascular coupling in brain injury.

Original languageEnglish (US)
Title of host publicationCerebral Vasospasm
Subtitle of host publicationNeurovascular Events After Subarachnoid Hemorrhage
PublisherSpringer-Verlag Wien
Pages161-165
Number of pages5
ISBN (Print)9783709111918
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameActa Neurochirurgica, Supplementum
Volume115
ISSN (Print)0065-1419
ISSN (Electronic)0001-6268

Keywords

  • Cerebral perfusion
  • Cortical spreading depolarizations
  • Electrocorticography
  • Neurovascular coupling

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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