Neutrophil-lymphocyte ratio is associated with arterial stiffness in postmenopausal women with osteoporosis

Xin yang Yu, Xue song Li, Ying Li, Tiemin Liu, Rui tao Wang

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Objective: Systemic inflammation may be a common mechanism for the development of osteoporosis (OP) and atherosclerosis. Elevated arterial stiffness is an index of subclinical atherosclerosis. Recent studies found that neutrophil/lymphocyte ratio (NLR), is a useful marker of cardiovascular disease and a more powerful predictor than any other leukocyte subtypes. However, little research has been conducted to investigate the relationship between NLR and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). Methods: In this cross-sectional study, we examined the relationship between NLR and baPWV in 512 subjects. Results: Compared to the control subjects, NLR and baPWV increased in patients with OP. Partial correlation analysis revealed that there was a significant correlation between NLR and baPWV after adjusting for confounding factors in OP. Multivariate linear regression analysis showed that NLR was a significant factor for increased baPWV in patients with OP (. β=. 0.249, p<. 0.001). However, there was no association between NLR and baPWV in control subjects. Conclusion: NLR and baPWV are elevated in OP. Moreover, NLR is independently associated with baPWV. Further studies are warranted to investigate whether anti-inflammatory treatment could improve arterial stiffness in postmenopausal women with OP.

Original languageEnglish (US)
Pages (from-to)76-80
Number of pages5
JournalArchives of Gerontology and Geriatrics
Volume61
Issue number1
DOIs
StatePublished - Jul 1 2015

Keywords

  • Arterial stiffness
  • Brachial-ankle pulse wave velocity
  • Inflammation
  • Neutrophil-lymphocyte ratio
  • Osteoporosis

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Health(social science)
  • Gerontology

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