Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion

D. L. Walden, H. McCutchan, E. G. Enquist, J. R. Schwappach, P. F. Shanley, O. K. Reiss, L. S. Terada, J. A. Leff, J. E. Repine

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3 h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume259
Issue number6 28-6
StatePublished - 1990

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Reperfusion
Skeletal Muscle
Neutrophils
Ischemia
Vinblastine
Edema

Keywords

  • blood neutrophils
  • vinblastine

ASJC Scopus subject areas

  • Physiology

Cite this

Walden, D. L., McCutchan, H., Enquist, E. G., Schwappach, J. R., Shanley, P. F., Reiss, O. K., ... Repine, J. E. (1990). Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion. American Journal of Physiology - Heart and Circulatory Physiology, 259(6 28-6).

Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion. / Walden, D. L.; McCutchan, H.; Enquist, E. G.; Schwappach, J. R.; Shanley, P. F.; Reiss, O. K.; Terada, L. S.; Leff, J. A.; Repine, J. E.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 259, No. 6 28-6, 1990.

Research output: Contribution to journalArticle

Walden, DL, McCutchan, H, Enquist, EG, Schwappach, JR, Shanley, PF, Reiss, OK, Terada, LS, Leff, JA & Repine, JE 1990, 'Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion', American Journal of Physiology - Heart and Circulatory Physiology, vol. 259, no. 6 28-6.
Walden, D. L. ; McCutchan, H. ; Enquist, E. G. ; Schwappach, J. R. ; Shanley, P. F. ; Reiss, O. K. ; Terada, L. S. ; Leff, J. A. ; Repine, J. E. / Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion. In: American Journal of Physiology - Heart and Circulatory Physiology. 1990 ; Vol. 259, No. 6 28-6.
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AU - Shanley, P. F.

AU - Reiss, O. K.

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