Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion

D. L. Walden; H. McCutchan; E. G. Enquist; J. R. Schwappach; P. F. Shanley; O. K. Reiss; L. S. Terada; J. A. Leff; J. E. Repine

doi:10.1152/ajpheart.1990.259.6.h1809

Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion

D. L. Walden, H. McCutchan, E. G. Enquist, J. R. Schwappach, P. F. Shanley, O. K. Reiss, L. S. Terada, J. A. Leff, J. E. Repine

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3 h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.

Original language	English (US)
Pages (from-to)	H1809-H1812
Journal	American Journal of Physiology - Heart and Circulatory Physiology
Volume	259
Issue number	6 28-6
DOIs	https://doi.org/10.1152/ajpheart.1990.259.6.h1809
State	Published - 1990

Keywords

blood neutrophils
vinblastine

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1152/ajpheart.1990.259.6.h1809

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Walden, D. L., McCutchan, H., Enquist, E. G., Schwappach, J. R., Shanley, P. F., Reiss, O. K., Terada, L. S., Leff, J. A., & Repine, J. E. (1990). Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion. American Journal of Physiology - Heart and Circulatory Physiology, 259(6 28-6), H1809-H1812. https://doi.org/10.1152/ajpheart.1990.259.6.h1809

Walden, DL, McCutchan, H, Enquist, EG, Schwappach, JR, Shanley, PF, Reiss, OK, Terada, LS, Leff, JA & Repine, JE 1990, 'Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion', American Journal of Physiology - Heart and Circulatory Physiology, vol. 259, no. 6 28-6, pp. H1809-H1812. https://doi.org/10.1152/ajpheart.1990.259.6.h1809

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title = "Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion",

abstract = "Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3 h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.",

keywords = "blood neutrophils, vinblastine",

author = "Walden, {D. L.} and H. McCutchan and Enquist, {E. G.} and Schwappach, {J. R.} and Shanley, {P. F.} and Reiss, {O. K.} and Terada, {L. S.} and Leff, {J. A.} and Repine, {J. E.}",

year = "1990",

doi = "10.1152/ajpheart.1990.259.6.h1809",

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T1 - Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion

AU - Walden, D. L.

AU - McCutchan, H.

AU - Enquist, E. G.

AU - Schwappach, J. R.

AU - Shanley, P. F.

AU - Reiss, O. K.

AU - Terada, L. S.

AU - Leff, J. A.

AU - Repine, J. E.

PY - 1990

Y1 - 1990

N2 - Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3 h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.

AB - Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3 h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.

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KW - vinblastine

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ER -

Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion

Abstract

Keywords

ASJC Scopus subject areas

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