New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelos Evangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, Ibrahim Karaman, Joshua Elliott, Qiang Luo, Stefanie Aeschbacher, Traci M. Bartz, Sebastian E. Baumeister, Peter S. Braund, Michael R. Brown, Jennifer A. Brody, Toni Kim ClarkeNiki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A. Kentistou, Peter K. Joshi, Rozenn N. Lemaitre, Penelope A. Lind, Leo Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Christopher P. Nelson, Ilja M. Nolte, Mia Maria Perälä, Ozren Polasek, David Porteous, Scott M. Ratliff, Jennifer A. Smith, Alena Stančáková, Alexander Teumer, Samuli Tuominen, Sébastien Thériault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E. Arking, Juha Auvinen, Chunyu Liu, Minna Männikkö, Lorenz Risch, Jerome I. Rotter, Harold Snieder, Juha Veijola, Alexandra I. Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J. Grabe, Xiuqing Guo, Pim van der Harst, Catharina A. Hartman, Caroline Hayward, Andrew C. Heath, Marjo Riitta Jarvelin, Mika Kähönen, Sharon L.R. Kardia, Michael Kühne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas G. Martin, Albertine J. Oldehinkel, Brenda W.J.H. Penninx, Bruce M. Psaty, Olli T. Raitakari, Igor Rudan, Nilesh J. Samani, Laura J. Scott, Tim D. Spector, Niek Verweij, David R. Weir, James F. Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D. Bell, Paul M. Matthews, Adrian Rothenfluh, Sylvane Desrivières, Gunter Schumann, Paul Elliott

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Original languageEnglish (US)
Pages (from-to)950-961
Number of pages12
JournalNature Human Behaviour
Volume3
Issue number9
DOIs
StatePublished - Sep 1 2019
Externally publishedYes

Fingerprint

Alcohol Drinking
Alcohols
Genes
Genome-Wide Association Study
Meta-Analysis
Cause of Death
Schizophrenia
Epidemiology
Magnetic Resonance Imaging
Genome
Gene Expression
Research

ASJC Scopus subject areas

  • Social Psychology
  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Evangelou, E., Gao, H., Chu, C., Ntritsos, G., Blakeley, P., Butts, A. R., ... Elliott, P. (2019). New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature Human Behaviour, 3(9), 950-961. https://doi.org/10.1038/s41562-019-0653-z

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. / Evangelou, Evangelos; Gao, He; Chu, Congying; Ntritsos, Georgios; Blakeley, Paul; Butts, Andrew R.; Pazoki, Raha; Suzuki, Hideaki; Koskeridis, Fotios; Yiorkas, Andrianos M.; Karaman, Ibrahim; Elliott, Joshua; Luo, Qiang; Aeschbacher, Stefanie; Bartz, Traci M.; Baumeister, Sebastian E.; Braund, Peter S.; Brown, Michael R.; Brody, Jennifer A.; Clarke, Toni Kim; Dimou, Niki; Faul, Jessica D.; Homuth, Georg; Jackson, Anne U.; Kentistou, Katherine A.; Joshi, Peter K.; Lemaitre, Rozenn N.; Lind, Penelope A.; Lyytikäinen, Leo Pekka; Mangino, Massimo; Milaneschi, Yuri; Nelson, Christopher P.; Nolte, Ilja M.; Perälä, Mia Maria; Polasek, Ozren; Porteous, David; Ratliff, Scott M.; Smith, Jennifer A.; Stančáková, Alena; Teumer, Alexander; Tuominen, Samuli; Thériault, Sébastien; Vangipurapu, Jagadish; Whitfield, John B.; Wood, Alexis; Yao, Jie; Yu, Bing; Zhao, Wei; Arking, Dan E.; Auvinen, Juha; Liu, Chunyu; Männikkö, Minna; Risch, Lorenz; Rotter, Jerome I.; Snieder, Harold; Veijola, Juha; Blakemore, Alexandra I.; Boehnke, Michael; Campbell, Harry; Conen, David; Eriksson, Johan G.; Grabe, Hans J.; Guo, Xiuqing; van der Harst, Pim; Hartman, Catharina A.; Hayward, Caroline; Heath, Andrew C.; Jarvelin, Marjo Riitta; Kähönen, Mika; Kardia, Sharon L.R.; Kühne, Michael; Kuusisto, Johanna; Laakso, Markku; Lahti, Jari; Lehtimäki, Terho; McIntosh, Andrew M.; Mohlke, Karen L.; Morrison, Alanna C.; Martin, Nicholas G.; Oldehinkel, Albertine J.; Penninx, Brenda W.J.H.; Psaty, Bruce M.; Raitakari, Olli T.; Rudan, Igor; Samani, Nilesh J.; Scott, Laura J.; Spector, Tim D.; Verweij, Niek; Weir, David R.; Wilson, James F.; Levy, Daniel; Tzoulaki, Ioanna; Bell, Jimmy D.; Matthews, Paul M.; Rothenfluh, Adrian; Desrivières, Sylvane; Schumann, Gunter; Elliott, Paul.

In: Nature Human Behaviour, Vol. 3, No. 9, 01.09.2019, p. 950-961.

Research output: Contribution to journalArticle

Evangelou, E, Gao, H, Chu, C, Ntritsos, G, Blakeley, P, Butts, AR, Pazoki, R, Suzuki, H, Koskeridis, F, Yiorkas, AM, Karaman, I, Elliott, J, Luo, Q, Aeschbacher, S, Bartz, TM, Baumeister, SE, Braund, PS, Brown, MR, Brody, JA, Clarke, TK, Dimou, N, Faul, JD, Homuth, G, Jackson, AU, Kentistou, KA, Joshi, PK, Lemaitre, RN, Lind, PA, Lyytikäinen, LP, Mangino, M, Milaneschi, Y, Nelson, CP, Nolte, IM, Perälä, MM, Polasek, O, Porteous, D, Ratliff, SM, Smith, JA, Stančáková, A, Teumer, A, Tuominen, S, Thériault, S, Vangipurapu, J, Whitfield, JB, Wood, A, Yao, J, Yu, B, Zhao, W, Arking, DE, Auvinen, J, Liu, C, Männikkö, M, Risch, L, Rotter, JI, Snieder, H, Veijola, J, Blakemore, AI, Boehnke, M, Campbell, H, Conen, D, Eriksson, JG, Grabe, HJ, Guo, X, van der Harst, P, Hartman, CA, Hayward, C, Heath, AC, Jarvelin, MR, Kähönen, M, Kardia, SLR, Kühne, M, Kuusisto, J, Laakso, M, Lahti, J, Lehtimäki, T, McIntosh, AM, Mohlke, KL, Morrison, AC, Martin, NG, Oldehinkel, AJ, Penninx, BWJH, Psaty, BM, Raitakari, OT, Rudan, I, Samani, NJ, Scott, LJ, Spector, TD, Verweij, N, Weir, DR, Wilson, JF, Levy, D, Tzoulaki, I, Bell, JD, Matthews, PM, Rothenfluh, A, Desrivières, S, Schumann, G & Elliott, P 2019, 'New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders', Nature Human Behaviour, vol. 3, no. 9, pp. 950-961. https://doi.org/10.1038/s41562-019-0653-z
Evangelou, Evangelos ; Gao, He ; Chu, Congying ; Ntritsos, Georgios ; Blakeley, Paul ; Butts, Andrew R. ; Pazoki, Raha ; Suzuki, Hideaki ; Koskeridis, Fotios ; Yiorkas, Andrianos M. ; Karaman, Ibrahim ; Elliott, Joshua ; Luo, Qiang ; Aeschbacher, Stefanie ; Bartz, Traci M. ; Baumeister, Sebastian E. ; Braund, Peter S. ; Brown, Michael R. ; Brody, Jennifer A. ; Clarke, Toni Kim ; Dimou, Niki ; Faul, Jessica D. ; Homuth, Georg ; Jackson, Anne U. ; Kentistou, Katherine A. ; Joshi, Peter K. ; Lemaitre, Rozenn N. ; Lind, Penelope A. ; Lyytikäinen, Leo Pekka ; Mangino, Massimo ; Milaneschi, Yuri ; Nelson, Christopher P. ; Nolte, Ilja M. ; Perälä, Mia Maria ; Polasek, Ozren ; Porteous, David ; Ratliff, Scott M. ; Smith, Jennifer A. ; Stančáková, Alena ; Teumer, Alexander ; Tuominen, Samuli ; Thériault, Sébastien ; Vangipurapu, Jagadish ; Whitfield, John B. ; Wood, Alexis ; Yao, Jie ; Yu, Bing ; Zhao, Wei ; Arking, Dan E. ; Auvinen, Juha ; Liu, Chunyu ; Männikkö, Minna ; Risch, Lorenz ; Rotter, Jerome I. ; Snieder, Harold ; Veijola, Juha ; Blakemore, Alexandra I. ; Boehnke, Michael ; Campbell, Harry ; Conen, David ; Eriksson, Johan G. ; Grabe, Hans J. ; Guo, Xiuqing ; van der Harst, Pim ; Hartman, Catharina A. ; Hayward, Caroline ; Heath, Andrew C. ; Jarvelin, Marjo Riitta ; Kähönen, Mika ; Kardia, Sharon L.R. ; Kühne, Michael ; Kuusisto, Johanna ; Laakso, Markku ; Lahti, Jari ; Lehtimäki, Terho ; McIntosh, Andrew M. ; Mohlke, Karen L. ; Morrison, Alanna C. ; Martin, Nicholas G. ; Oldehinkel, Albertine J. ; Penninx, Brenda W.J.H. ; Psaty, Bruce M. ; Raitakari, Olli T. ; Rudan, Igor ; Samani, Nilesh J. ; Scott, Laura J. ; Spector, Tim D. ; Verweij, Niek ; Weir, David R. ; Wilson, James F. ; Levy, Daniel ; Tzoulaki, Ioanna ; Bell, Jimmy D. ; Matthews, Paul M. ; Rothenfluh, Adrian ; Desrivières, Sylvane ; Schumann, Gunter ; Elliott, Paul. / New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. In: Nature Human Behaviour. 2019 ; Vol. 3, No. 9. pp. 950-961.
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AU - Evangelou, Evangelos

AU - Gao, He

AU - Chu, Congying

AU - Ntritsos, Georgios

AU - Blakeley, Paul

AU - Butts, Andrew R.

AU - Pazoki, Raha

AU - Suzuki, Hideaki

AU - Koskeridis, Fotios

AU - Yiorkas, Andrianos M.

AU - Karaman, Ibrahim

AU - Elliott, Joshua

AU - Luo, Qiang

AU - Aeschbacher, Stefanie

AU - Bartz, Traci M.

AU - Baumeister, Sebastian E.

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AU - Clarke, Toni Kim

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AU - Joshi, Peter K.

AU - Lemaitre, Rozenn N.

AU - Lind, Penelope A.

AU - Lyytikäinen, Leo Pekka

AU - Mangino, Massimo

AU - Milaneschi, Yuri

AU - Nelson, Christopher P.

AU - Nolte, Ilja M.

AU - Perälä, Mia Maria

AU - Polasek, Ozren

AU - Porteous, David

AU - Ratliff, Scott M.

AU - Smith, Jennifer A.

AU - Stančáková, Alena

AU - Teumer, Alexander

AU - Tuominen, Samuli

AU - Thériault, Sébastien

AU - Vangipurapu, Jagadish

AU - Whitfield, John B.

AU - Wood, Alexis

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AU - Yu, Bing

AU - Zhao, Wei

AU - Arking, Dan E.

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AU - Liu, Chunyu

AU - Männikkö, Minna

AU - Risch, Lorenz

AU - Rotter, Jerome I.

AU - Snieder, Harold

AU - Veijola, Juha

AU - Blakemore, Alexandra I.

AU - Boehnke, Michael

AU - Campbell, Harry

AU - Conen, David

AU - Eriksson, Johan G.

AU - Grabe, Hans J.

AU - Guo, Xiuqing

AU - van der Harst, Pim

AU - Hartman, Catharina A.

AU - Hayward, Caroline

AU - Heath, Andrew C.

AU - Jarvelin, Marjo Riitta

AU - Kähönen, Mika

AU - Kardia, Sharon L.R.

AU - Kühne, Michael

AU - Kuusisto, Johanna

AU - Laakso, Markku

AU - Lahti, Jari

AU - Lehtimäki, Terho

AU - McIntosh, Andrew M.

AU - Mohlke, Karen L.

AU - Morrison, Alanna C.

AU - Martin, Nicholas G.

AU - Oldehinkel, Albertine J.

AU - Penninx, Brenda W.J.H.

AU - Psaty, Bruce M.

AU - Raitakari, Olli T.

AU - Rudan, Igor

AU - Samani, Nilesh J.

AU - Scott, Laura J.

AU - Spector, Tim D.

AU - Verweij, Niek

AU - Weir, David R.

AU - Wilson, James F.

AU - Levy, Daniel

AU - Tzoulaki, Ioanna

AU - Bell, Jimmy D.

AU - Matthews, Paul M.

AU - Rothenfluh, Adrian

AU - Desrivières, Sylvane

AU - Schumann, Gunter

AU - Elliott, Paul

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