@article{0897b7d073ff4625adf00c4f66319da6,
title = "New Approaches to SCLC Therapy: From the Laboratory to the Clinic",
abstract = "The outcomes of patients with SCLC have not yet been substantially impacted by the revolution in precision oncology, primarily owing to a paucity of genetic alterations in actionable driver oncogenes. Nevertheless, systemic therapies that include immunotherapy are beginning to show promise in the clinic. Although, these results are encouraging, many patients do not respond to, or rapidly recur after, current regimens, necessitating alternative or complementary therapeutic strategies. In this review, we discuss ongoing investigations into the pathobiology of this recalcitrant cancer and the therapeutic vulnerabilities that are exposed by the disease state. Included within this discussion, is a snapshot of the current biomarker and clinical trial landscapes for SCLC. Finally, we identify key knowledge gaps that should be addressed to advance the field in pursuit of reduced SCLC mortality. This review largely summarizes work presented at the Third Biennial International Association for the Study of Lung Cancer SCLC Meeting.",
keywords = "ASCL1, Gene mutations, Neuroendocrine, SCLC, Therapy",
author = "Poirier, {John T.} and Julie George and Owonikoko, {Taofeek K.} and Anton Berns and Elisabeth Brambilla and Byers, {Lauren A.} and David Carbone and Chen, {Huanhuan J.} and Christensen, {Camilla L.} and Caroline Dive and Farago, {Anna F.} and Ramaswamy Govindan and Christine Hann and Hellmann, {Matthew D.} and Leora Horn and Johnson, {Jane E.} and Ju, {Young S.} and Sumin Kang and Mark Krasnow and James Lee and Lee, {Se Hoon} and Jonathan Lehman and Benjamin Lok and Christine Lovly and David MacPherson and David McFadden and John Minna and Matthew Oser and Keunchil Park and Park, {Kwon Sik} and Yves Pommier and Vito Quaranta and Neal Ready and Julien Sage and Giorgio Scagliotti and Sos, {Martin L.} and Sutherland, {Kate D.} and Travis, {William D.} and Vakoc, {Christopher R.} and Wait, {Sarah J.} and Ignacio Wistuba and Wong, {Kwok Kin} and Hua Zhang and Jillian Daigneault and Jacinta Wiens and Rudin, {Charles M.} and Oliver, {Trudy G.}",
note = "Funding Information: The authors were supported by grants from the National Institutes of Health (NIH) R01 CA213448 (Dr. Poirier and Dr. Rudin), U01 CA213359 (Dr. Poirier), U01 CA231844 (Dr. Oliver and Dr. Govindan), U24 CA213274 (Dr. Rudin and Dr. Oliver), U01 CA213338 (Dr. Minna), R21 CA216504 (Dr. Oliver), and R01 CA207295 (Dr. Byers). The NCI Small Cell Research Consortium Coordinating Center ( U24 CA213274 ) and the International Association for the Study of Lung Cancer supported the meeting on which this review is based. The authors also thank Dr. Peter Ujhazy, Dr. Eva Szabo, and Dr. Suzanne Forry from the National Cancer Institute (NCI), and Dr. Adi Gazdar, whose pioneering work has greatly impacted the discoveries described in this study, and to whom the Third Biennial International Association for the Study of Lung Cancer (IASLC) SCLC meeting and this manuscript was dedicated to.",
year = "2020",
month = apr,
doi = "10.1016/j.jtho.2020.01.016",
language = "English (US)",
volume = "15",
pages = "520--540",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "4",
}