New frontiers and developing applications in 19F NMR

Jian Xin Yu, Rami R. Hallac, Srinivas Chiguru, Ralph P. Mason

89 Scopus citations

Abstract

The 19F NMR is gaining interest as a tool for diverse physiological and pharmaceutical investigations. The relatively high sensitivity of 19F and lack of interfering background signal in the body have enabled the observation of exogenously administered agents and their metabolites. The high gyromagnetic ratio often allows the use of existing proton NMR instrumentation with the minimum of component adjustments. 19F NMR is particularly attractive for in vivo applications since there is essentially no endogenous signal from tissues. 19F is exceptionally sensitive to molecular and microenvironmental changes as exemplified by the many 19F-based reporter molecules designed to interrogate physiological phenomena in vivo. The presence of the 19F atom may modulate molecular properties, most notably hydrophobicity and this becomes more significant for multiple fluorines, as encountered in CF3 groups.

Original languageEnglish (US)
Pages (from-to)25-49
Number of pages25
JournalProgress in Nuclear Magnetic Resonance Spectroscopy
Volume70
DOIs
Publication statusPublished - Apr 2013

    Fingerprint

Keywords

  • β-Galactosidase
  • Enzyme activity
  • Fluorine
  • Hypoxia
  • Metal ions
  • NMR
  • pH

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Nuclear and High Energy Physics
  • Materials Science(all)
  • Biochemistry

Cite this