New functions for an ancient domain

Research output: Contribution to journalShort surveypeer-review

31 Scopus citations


Macrodomains function as binding modules for metabolites of NAD +, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair.

Original languageEnglish (US)
Pages (from-to)904-907
Number of pages4
JournalNature Structural and Molecular Biology
Issue number9
StatePublished - Sep 2009

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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